10.18453/rosdok_id00000318
Hoffmann, Eik
Eik
Hoffmann
http://d-nb.info/gnd/135691915
The influence of receptor-ligand interactions on gene expression and phagosome functions in mouse macrophages
Universität Rostock
2007
570 Life science
2007
en
http://purl.uni-rostock.de/rosdok/id00000318
urn:nbn:de:gbv:28-diss2008-0050-9
Phagocytosis, the cellular uptake of particles and pathogens, is an essential function of the innate immune response. In this study, latex beads conjugated to immunoglobulin G, bacterial lipopolysaccharides, mannan or avidin were used to induce the internalization via different phagocytic receptors. Analysis of uptake and maturation of phagosomes, their proteomes as well as of macrophage gene expression during phagocytosis demonstrated that receptor-ligand interactions at the cell surface trigger a specfic signaling 'signature', which contributes to the intracellular fate of phagosomes.