10.18453/rosdok_id00000362
Krüger, Karolin
Karolin
Krüger
http://d-nb.info/gnd/136535313
Synthesis of Biologically Active N-Heterocycles and Amines via Catalytic Hydroamination of Alkynes
Universität Rostock
2008
540 Chemistry & allied sciences
2008
en
http://purl.uni-rostock.de/rosdok/id00000362
urn:nbn:de:gbv:28-diss2008-0096-0
This thesis presents new syntheses of N-heterocycles and amines. Building up on our prior studies in titanium-catalyzed hydroamination of alkynes we discovered zinc salts as new hydroamination catalysts. Zinc chloride and zinc triflate were successfully applied in the intermolecular hydroamination of terminal alkynes for the synthesis of various substituted indole derivatives, pyrazolines and pyrazoles, pyridazinones as well as amines. Additional functionalization reactions on special synthesized indole structures lead to pharmaceutically and biologically interesting substances.