10.18453/rosdok_id00000764
Ahmad, Syed Furquan
Syed Furquan
Ahmad
http://d-nb.info/gnd/143082981
Influence of Fcγ receptor distribution on mannose receptor mediated phagocytosis
Universität Rostock
2010
570 Life science
2010
en
http://purl.uni-rostock.de/rosdok/id00000764
urn:nbn:de:gbv:28-diss2010-0189-0
In this study the recognition maps obtained by the simultaneous topography and recognition (TREC) imaging revealed that Fcγ receptors are distributed in micro-domains of sizes 4nm to 200nm. The fluorescent and electron-microscopy provided further evidence that these clusters are located within close proximity of mannose receptors. This pattern of distribution of FcγRs and MRs led to inhibition of the MR mediated mediated phagocytosis. The data presented in this thesis provide evidences of cross-talk between FcγR mediated and MR mediated phagocytosis.