10.18453/rosdok_id00000844
Wang, Weiwei
Weiwei
Wang
http://d-nb.info/gnd/1011739771
Polymer mediated gene delivery for adult stem cell therapy
Polymervermittelter Gentransfer für die Therapie mit adulten Stammzellen
Universität Rostock
2010
610 Medical sciences Medicine
2010
en
http://purl.uni-rostock.de/rosdok/id00000844
urn:nbn:de:gbv:28-diss2011-0070-9
Polymer mediated gene delivery was studied and utilized in adult stem cell therapy. The gene expression of human mesenchymal stem cells (MSCs) could be significantly enhanced by polyethylenimine (PEI) mediated gene delivery. The tumor cell growth could be effectively inhibited both in vitro and in vivo by delivering antisense oligonucleotide with non-viral method. Furthermore, gene activated substrate (GAS) prepared in this study could allow localized gene delivery, sustained gene release, high transfection efficiency, low cytotoxicity and high potential for stem cell recruitment.