10.18453/rosdok_id00001000
Ali, Iftikhar
Iftikhar
Ali
http://d-nb.info/gnd/1023711575
Synthesis of Substituted 1-Deazapurines via Pd/Cu Catalysed C-H Activation, Substituted Naphthyridines, Quinoxalines, and Trifluoromethyl-Substituted Arenes by Pd(0)-Catalysed Cross-Coupling Reactions
Universität Rostock
2011
540 Chemistry & allied sciences
2011
en
http://purl.uni-rostock.de/rosdok/id00001000
urn:nbn:de:gbv:28-diss2012-0039-6
The Pd/Cu catalyzed reactions of 3H-imidazo[4,5-b]pyridines (1-deazapurines) via C-H bond activation provided arylated 1-deazapurines. The arylation took place at position 2 of the 1-deazapurines. Pd(0)-catalysed Suzuki-Miyaura cross coupling reactions of 5,7-dichloro-1,6-naphthyridine, 2,6-dichloroquinoxaline and 2,4-dichloro-1-(trifluoromethyl)benzene with different arylboronic acids afforded aryl-substituted naphthyridines, quinoxalines and trifluoromethyl-substituted di- and terphenyls with excellent site-selectivity. The first attack occurred at the more electronically deficient and sterically less hindered position.