10.18453/rosdok_id00001001
Ma, Nan
Nan
Ma
http://d-nb.info/gnd/136129765
Stem cell manipulation and cardiac regeneration
Stammzell-Manipulation und kardiale Regeneration
Universität Rostock
2009
610 Medical sciences Medicine
2009
en
http://purl.uni-rostock.de/rosdok/id00001001
urn:nbn:de:gbv:28-diss2012-0040-8
Stem cell therapy holds great promise in the treatment of cardiac disease. A major limitation to the efficacy of cell therapy is the poor viability of the transplanted cells. Our present studies revealed that genetic modification of MSCs effectively protects transplanted MSCs against ischemia and increases cell survival after implantation. Continued development and application of genetic manipulation approaches in stem cells will undoubtedly lead to more efficient guidance and control of stem cell fate and improved stem cell function.