10.18453/rosdok_id00001444
Du, Yang
Yang
Du
http://d-nb.info/gnd/1062825780
Functional characterization and annotation of trait-associated genomic regions by transcriptome analysis
Universität Rostock
2014
000 Generalities, Science
570 Life science
2014
en
http://purl.uni-rostock.de/rosdok/id00001444
urn:nbn:de:gbv:28-diss2014-0196-0
In this work, two novel implementations have been presented, which could assist in the design and data analysis of high-throughput genomic experiments. An efficient and flexible tiling probe selection pipeline utilizing the penalized uniqueness score has been implemented, which could be employed in the design of various types and scales of genome tiling task. A novel hidden semi-Markov model (HSMM) implementation is made available within the Bioconductor project, which provides a unified interface for segmenting genomic data in a wide range of research subjects.