10.18453/rosdok_id00002278
Apelt, Helena
Helena
Apelt
http://d-nb.info/gnd/1163020869
Potential intermediates for antiviral and antitumor agents
Universität Rostock
2018
540 Chemistry & allied sciences
2018
en
http://purl.uni-rostock.de/rosdok/id00002278
urn:nbn:de:gbv:28-diss2018-0112-8
In this work, potential intermediates for antiviral and antitumor agents were successfully synthesized. This thesis is focused on the development of the 2-deoxy-D-ribofuranose analogues, due to the similarity with DNA building blocks, with diamine moieties that should be able to form metal complexes similar to cisplatin. This thesis deals with the synthesis and characterization of C-nucleoside analogues of D-ribose. In addition, we have succeeded in obtaining several 2-deoxy-D-ribofuranose derivatives with ethylenediamine group on a spacer with one or three carbon atoms to the sugar moiety.