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Schwarz,  Nicolle

Synthesis and Catalytic Functionalization of Biologically Active Indoles

Rostock : Universität , 2008

https://doi.org/10.18453/rosdok_id00000427

http://purl.uni-rostock.de/rosdok/id00000427

Abstract:

Of fundamental importance in nature are substituted indoles. The thesis presents the synthesis of new indole derivatives and their functionalization to potential 5-HT6 receptor ligands. Based on our prior synthesis to indole analogues we investigated a synthetic strategy to innovative indole scaffolds via Ti- or Zn-catalyzed hydrohydrazination of terminal alkynes. We developed the pharmaceutical interesting class of 3-silyloxyindoles and their further application in several catalytic reactions. Buchwald-Hartwig amination, C-O cross- coupling and sulfonylation were utilized and optimized.

Dissertation Open Access


Einrichtung :
Mathematisch-Naturwissenschaftliche Fakultät
Gutachter :
Beller,  Matthias  (Prof. Dr.)
Börner,  Armin  (Prof. Dr.)
Jahr der Abgabe:
2008
Jahr der Verteidigung:
2008
Sprache(n) :
Englisch
Schlagworte:
Homogenous Catalysis, Cross-Coupling Reaction, Buchwald-Hartwig Amination
DDC Klassifikation :
540 Chemie
URN :
urn:nbn:de:gbv:28-diss2009-0035-0
Persistente URL:
http://purl.uni-rostock.de/rosdok/id00000427
erstellt am:
2009-02-27
zuletzt geändert am:
2018-06-30
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