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Tetzlaff,  Sylvio

Identification and analysis of functional candidate genes for the inverted teat defect in pigs

Rostock : Universität , 2009

https://doi.org/10.18453/rosdok_id00000535

http://purl.uni-rostock.de/rosdok/id00000535

Abstract:

PTHR1 and LEF1 were analyzed as functional candidate genes for the inverted teat defect in pigs. SNP in both genes could be shown as significantly associated with inverted teats. QTL analyses revealed significant QTL on twelve chromosomes in an experimental and five chromosomes in a commercial pig population. That enabled the information about novel positional candidate genes. Adjacent microarray analyses of epithelial and mesenchymal teat tissues of affected and non-affected animals offered differentially regulated genes. Constitutive quantitative real-time analyses of FGFR2, GHR, HGF, PDGFA, PDGFRA, PDGFB and VEGF revealed significant differential expressions in the compared tissues.

Dissertation Open Access


Einrichtung :
Mathematisch-Naturwissenschaftliche Fakultät
Gutachter :
Schröder,  Reinhard  (Prof. Dr.)
Wimmers,  Klaus  (Prof. Dr.)
Schellander,  Karl  (Prof. Dr.)
Jahr der Abgabe:
2008
Jahr der Verteidigung:
2009
Sprache(n) :
Englisch
Schlagworte:
inherited disorder, liability traits, expression profile, QTL, family based association
DDC Klassifikation :
590 Tiere (Zoologie)
570 Biowissenschaften, Biologie
URN :
urn:nbn:de:gbv:28-diss2009-0154-1
Persistente URL:
http://purl.uni-rostock.de/rosdok/id00000535
erstellt am:
2010-04-21
zuletzt geändert am:
2018-06-30
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