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Wang,  Xinchao

Streptamer technology allows to isolate leukemia antigen-specific CD8+ T cells

Rostock : Universität , 2009

https://doi.org/10.18453/rosdok_id00000571

http://purl.uni-rostock.de/rosdok/id00000571

In this work we investigated whether streptamer technology could purify WT1-specific CD8+ T cells, what is important for the development of adoptive immunotherapy. Sample from HLA/A2+ HDs were identified and selected by streptamer. The function of selected CD8+ T cells was identified by the staining of phenotypic markers. The results showed that streptamer permits the detection and selection of WT1-specific CD8+ T cells in the PBMCs from HDs. The naïve function of selected CD8+ T cells was preserved and most selected CD8+ T cells demonstrated an effector T cell immunophenotype.

Dissertation Open Access


Einrichtung :
Universitätsmedizin
Gutachter :
Schmitt,  Michael  (Prof. Dr. med.)
Greiner,  Jochen  (Prof. Dr. med.)
Klar,  Ernst  (Prof. Dr. med.)
Jahr der Abgabe:
2009
Jahr der Verteidigung:
2009
Sprache(n) :
Englisch
Schlagworte:
Multimer, WT-1, adoptive immunotherapy
DDC Klassifikation :
610 Medizin, Gesundheit
URN :
urn:nbn:de:gbv:28-diss2009-0196-0
Persistente URL:
http://purl.uni-rostock.de/rosdok/id00000571
erstellt am:
2009-11-30
zuletzt geändert am:
2018-06-30
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