Sprache(n) : |
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übersetzte Zusammenfassung
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The human neural VM197 progenitor cell line was studied to elucidate the interconnectivity of Wnt-driven cell determination and apoptosis. The cell differentiation was accompanied by an activation of pro- and anti-apoptotic proteins and an increase of apoptotic cell loss. Differentiated cells showed a diminished apoptosis susceptibility compared to proliferating cells. Beta-catenin cleavage and a significantly decreased apoptosis rate after the inhibition of GSK-3ß in differentiated cells indicate an interconnectivity of the canonical Wnt-signaling pathway and apoptosis. |
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Schlagworte: |
Apoptose, Nervenzellen, Wnt-Signalweg, apoptosis, neurons, Wnt-signaling pathway |
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DDC Klassifikation : |
570 Biowissenschaften, Biologie |
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