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Schmöle,  Anne-Caroline

Novel small molecules as GSK-3β inhibitors in human neural progenitor cells

Rostock : Universität , 2010

https://doi.org/10.18453/rosdok_id00000792

http://purl.uni-rostock.de/rosdok/id00000792

Abstract:

GSK-3β as the key enzyme of Wnt/β-catenin pathway is involved in various processes during the neuronal differentiation of stem and progenitor cells. Therefore small molecules are of great interest as they might provide new pharmacological tools to influence and study underlying mechanism. Thus, we developed a multi-level screening system to identify novel GSK-3β inhibitors. The influence on Wnt/β-catenin signaling was evaluated in human neural progenitor cells. New compounds raised the neuronal differentiation, whereat it was shown that the effect was due antagonistic action at GSK-3β.

Dissertation Open Access


Einrichtung :
Mathematisch-Naturwissenschaftliche Fakultät
Gutachter :
Rolfs,  Arndt  (Prof. Dr.)
Beller,  Matthias  (Prof. Dr.)
Kuznetsov,  Sergei  (PD Dr.)
Schwarz,  Johannes  (Prof. Dr.)
Jahr der Abgabe:
2010
Jahr der Verteidigung:
2011
Sprache(n) :
Englisch
Schlagworte:
GSK-3, Wnt, neurale Vorläuferzellen
DDC Klassifikation :
570 Biowissenschaften, Biologie
URN :
urn:nbn:de:gbv:28-diss2011-0014-9
Persistente URL:
http://purl.uni-rostock.de/rosdok/id00000792
erstellt am:
2011-03-10
zuletzt geändert am:
2018-06-30
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