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Patel, Devang
Rostock : Universität , 2010
https://doi.org/10.18453/rosdok_id00000797
http://purl.uni-rostock.de/rosdok/id00000797
In the current study annexin A1 was identified as a factor, which binds to latex beads phagosomes (LBP) and facilitates F-actin-LBP interaction in vitro. In macrophages the association of endogenous annexin A1 with LBP membranes is strongly correlated with F-actin accumulation at the LBP. Furthermore, it showed that receptor signalling influenced annexin A1 recruitment on different LBP. Reduction of annexin A1 expression resulted in impaired phagocytosis and actin flashing. These data revealed that annexin A1 as an important component of opsonic phagocytosis.
Dissertation
Open Access
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