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Patel,  Devang

Annexin A1 as a new functional linker between actin filaments and phagosomes during phagocytosis

Rostock : Universität , 2010

https://doi.org/10.18453/rosdok_id00000797

http://purl.uni-rostock.de/rosdok/id00000797

Abstract:

In the current study annexin A1 was identified as a factor, which binds to latex beads phagosomes (LBP) and facilitates F-actin-LBP interaction in vitro. In macrophages the association of endogenous annexin A1 with LBP membranes is strongly correlated with F-actin accumulation at the LBP. Furthermore, it showed that receptor signalling influenced annexin A1 recruitment on different LBP. Reduction of annexin A1 expression resulted in impaired phagocytosis and actin flashing. These data revealed that annexin A1 as an important component of opsonic phagocytosis.

Dissertation Open Access


Einrichtung :
Mathematisch-Naturwissenschaftliche Fakultät
Gutachter :
A. Kuznetsov,  Sergei  (PD Dr.)
Griffiths,  Gareth  (Prof. Dr.)
Jahr der Abgabe:
2010
Jahr der Verteidigung:
2011
Sprache(n) :
Englisch
Schlagworte:
receptor signalling, actin flashing, opsonic receptors, F-actin, calcium
DDC Klassifikation :
570 Biowissenschaften, Biologie
URN :
urn:nbn:de:gbv:28-diss2011-0019-0
Persistente URL:
http://purl.uni-rostock.de/rosdok/id00000797
erstellt am:
2012-03-13
zuletzt geändert am:
2018-06-30
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