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Thomas,  Saijo

Positive stranded RNA viruses  : Dissecting the capsid of Hepatitis E and Chikungunya viruses

Rostock : Universität , 2010

https://doi.org/10.18453/rosdok_id00000801

http://purl.uni-rostock.de/rosdok/id00000801

Abstract:

Capsid protein of two positive stranded RNA viruses, Hepatitis E virus (HEV) and Chikungunya virus (ChikV), were investigated. HEV was detected in swine serum collected in Germany. An infectious system for HEV was established and was used to check its egress. The requirement of various amino acid sequences for the autoproteolytic cleavage of ChikV capsid protease was investigated. I was also able to show that ChikV capsid is recognized by karyopherins and its export is mediated by CRM1 dependent nuclear export signal.

Dissertation Open Access


Einrichtung :
Mathematisch-Naturwissenschaftliche Fakultät
Gutachter :
Schaefer,  Stephan  (Prof. Dr. med.)
Bahl,  Hubert  (Prof. Dr. rer. nat.)
Jahr der Abgabe:
2010
Jahr der Verteidigung:
2011
Sprache(n) :
Englisch
Schlagworte:
capsid, HEV, ChikV, protease
DDC Klassifikation :
610 Medizin, Gesundheit
570 Biowissenschaften, Biologie
URN :
urn:nbn:de:gbv:28-diss2011-0024-4
Persistente URL:
http://purl.uni-rostock.de/rosdok/id00000801
erstellt am:
2012-03-13
zuletzt geändert am:
2018-06-30
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