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Wang,  Weiwei

Polymer mediated gene delivery for adult stem cell therapy

Rostock : Universität , 2010

https://doi.org/10.18453/rosdok_id00000844

http://purl.uni-rostock.de/rosdok/id00000844

Abstract:

Polymer mediated gene delivery was studied and utilized in adult stem cell therapy. The gene expression of human mesenchymal stem cells (MSCs) could be significantly enhanced by polyethylenimine (PEI) mediated gene delivery. The tumor cell growth could be effectively inhibited both in vitro and in vivo by delivering antisense oligonucleotide with non-viral method. Furthermore, gene activated substrate (GAS) prepared in this study could allow localized gene delivery, sustained gene release, high transfection efficiency, low cytotoxicity and high potential for stem cell recruitment.

Dissertation Open Access


Einrichtung :
Mathematisch-Naturwissenschaftliche Fakultät
Gutachter :
Steinhoff,  Gustav  (Prof. Dr. med.)
Weiss,  Dieter G.  (Prof. Dr. rer. nat.)
Klee,  Doris  (Prof. Dr. rer. nat.)
Jahr der Abgabe:
2010
Jahr der Verteidigung:
2011
Sprache(n) :
Englisch
übersetzter Titel :
Polymervermittelter Gentransfer für die Therapie mit adulten Stammzellen
Schlagworte:
polyethylenimine, non-viral gene therapy, gene activated substrate, stem cell recruitment, mesenchymal stem cells
DDC Klassifikation :
610 Medizin, Gesundheit
URN :
urn:nbn:de:gbv:28-diss2011-0070-9
Persistente URL:
http://purl.uni-rostock.de/rosdok/id00000844
erstellt am:
2011-05-13
zuletzt geändert am:
2018-06-30
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