Sprache(n) : |
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übersetzte Zusammenfassung
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Intestinal schistosomiasis is a parasitic disease in tropical and sub-tropical regions. The present work investigated the schistosomicidal potential of a “drug targeting” model and of the antimalarials mefloquine and primaquine. Additionally, the suitability of confocal laser scanning microscopy (CLSM) as a diagnostic tool was evaluated. A dose and time dependent schistosomicidal effect of albumin- and polyethylenglycol-conjugates and the antimalarials was demonstrated in vitro. CLSM visualises schistosomal eggs directly within gut tissue and permits determination of egg viability. |
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Schlagworte: |
Tropenkrankheiten, Helminthosen, Schistosoma mansoni, Anthelminthika, Konfokale Laser Scanning Mikroskopie |
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DDC Klassifikation : |
610 Medizin, Gesundheit |
590 Tiere (Zoologie) |
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