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Frey,  Simone

A systems biology approach to dynamic modelling of the AMP-activated kinase pathway

Rostock : Universität , 2011

https://doi.org/10.18453/rosdok_id00000904

http://purl.uni-rostock.de/rosdok/id00000904

A systems biology approach is used to investigate a key regulator of energy sensing, the AMPK/ Snf1 pathway. Therefore, a stimulus is derived considering transmembrane glucose transport. Fluorescent microscopy data of Mig1, a Snf1 pathway component, were processed through a mathematical approach. The data were compared to simulations of alternative network structures suggested to underlie the Snf1 pathway. Certain structures could be excluded. Besides, applying quantitative measures showed that the design of a MAPK pathway is favourable for the transmission of fast signals with short duration.

Dissertation Open Access


Einrichtung :
Fakultät für Informatik und Elektrotechnik
Gutachter :
Wolkenhauer,  Olaf  (Prof. (PhD))
Kummer,  Ursula  (Prof. Dr.)
Goksör,  Mattias  (Prof. Dr.)
Jahr der Abgabe:
2011
Jahr der Verteidigung:
2011
Sprache(n) :
Englisch
Schlagworte:
transduction, Snf1 pathway, quantitative measures, fluorescent microscopy, saccharomyces cerevisiae
DDC Klassifikation :
570 Biowissenschaften, Biologie
URN :
urn:nbn:de:gbv:28-diss2011-0135-1
Persistente URL:
http://purl.uni-rostock.de/rosdok/id00000904
erstellt am:
2011-11-10
zuletzt geändert am:
2018-06-30
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