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Mazemondet,  Orianne

Spatio-temporal Dynamics of the Wnt/beta-catenin Signaling Pathway  : A Computational Systems Biology Approach

Rostock : Universität , 2011

https://doi.org/10.18453/rosdok_id00000972

http://purl.uni-rostock.de/rosdok/id00000972

The Wnt/β-catenin signaling pathway is involved in human neural progenitor cell differentiation. This dissertation employs the cyclic workflow of computational systems biology to investigate the pathway spatio-temporal dynamics during differentiation. Quantitative in vitro analyses show biphasic kinetics of the pathway proteins. A computational model is developed to investigate in silico these kinetics in correlation with cell cycle and self-induced signaling. We show the importance of stochastic approach and suggest further experiments, hence closing the computational systems biology loop.

Dissertation Open Access


Einrichtung :
Fakultät für Informatik und Elektrotechnik
Gutachter :
Uhrmacher,  Adelinde M.  (Prof. Dr. rer. nat. habil.)
Rolfs,  Arndt  (Prof. Dr. med.)
Faeder,  James R.  (Prof. Dr.)
Jahr der Abgabe:
2011
Jahr der Verteidigung:
2011
Sprache(n) :
Englisch
Schlagworte:
computational systems biology, ReNcell VM cells, stochastic modeling, Systembiologie, Wnt/beta-catenin Signalweg, ReNcell VM Zellen, Stochastic Modellierung
DDC Klassifikation :
570 Biowissenschaften, Biologie
URN :
urn:nbn:de:gbv:28-diss2012-0005-4
Persistente URL:
http://purl.uni-rostock.de/rosdok/id00000972
erstellt am:
2012-02-01
zuletzt geändert am:
2018-06-30
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