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Orianne Mazemondet

Spatio-temporal Dynamics of the Wnt/beta-catenin Signaling Pathway:
A Computational Systems Biology Approach

Dissertation, Rostock, 2011
The Wnt/β-catenin signaling pathway is involved in human neural progenitor cell differentiation. This dissertation employs the cyclic workflow of computational systems biology to investigate the pathway spatio-temporal dynamics during differentiation. Quantitative in vitro analyses show biphasic kinetics of the pathway proteins. A computational model is developed to investigate in silico these kinetics in correlation with cell cycle and self-induced signaling. We show the importance of stochastic approach and suggest further experiments, hence closing the computational systems biology loop.
URL: http://rosdok.uni-rostock.de/resolve/id/rosdok_disshab_0000000787

Dokumente:
Dissertation_Mazemondet_2012.pdf (41,28 MB)

Einrichtung:
Fakultät für Informatik und Elektrotechnik
Gutachter:
Adelinde M. Uhrmacher (Prof. Dr. rer. nat. habil.)
Arndt Rolfs (Prof. Dr. med.)
James R. Faeder (Prof. Dr.)
Jahr der Abgabe:
2011
Jahr der Verteidigung:
2011

Schlagworte:
computational systems biology
ReNcell VM cells
stochastic modeling
Systembiologie
Wnt/beta-catenin Signalweg
ReNcell VM Zellen
Stochastic Modellierung
DDC Klassifikation:
570 Biowissenschaften; Biologie

URN:
urn:nbn:de:gbv:28-diss2012-0005-4

eingestellt am:
01. Februar 2012
letzte Änderung:
01. Februar 2012