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Zhuravleva, Nadezda
Rostock : Universität , 2011
https://doi.org/10.18453/rosdok_id00001056
http://purl.uni-rostock.de/rosdok/id00001056
KCNQ channels were recently found in the vascular system. We have tested the hypothesis that KCNQ channels are powerful targets for relaxation of small systemic and pulmonary arteries. In rat Gracilis arteries we found mRNA expression for KCNQ1, KCNQ3, KCNQ4 and KCNQ5 channels. We found that KCNQ channels mediate vessel relaxation induced by experimental modulators in systemic and pulmonary circulation, in normo- and hypertensive model. Conclusion: KCNQ channels could be powerful targets for vessel relaxation, also in pathological hypertensive conditions.
Dissertation
Open Access
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