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Zhuravleva,  Nadezda

KCNQ channel opening as a powerful mechanism for vasodilation

Rostock : Universität , 2011

https://doi.org/10.18453/rosdok_id00001056

http://purl.uni-rostock.de/rosdok/id00001056

Abstract:

KCNQ channels were recently found in the vascular system. We have tested the hypothesis that KCNQ channels are powerful targets for relaxation of small systemic and pulmonary arteries. In rat Gracilis arteries we found mRNA expression for KCNQ1, KCNQ3, KCNQ4 and KCNQ5 channels. We found that KCNQ channels mediate vessel relaxation induced by experimental modulators in systemic and pulmonary circulation, in normo- and hypertensive model. Conclusion: KCNQ channels could be powerful targets for vessel relaxation, also in pathological hypertensive conditions.

Dissertation Open Access


Einrichtung :
Universitätsmedizin
Gutachter :
Schubert,  Rudolf  (Prof. Dr. med.)
Gollasch,  Maik  (Prof. Dr. med. Dr. rer. nat.)
Grisk,  Olaf  (Prof. Dr. med.)
Jahr der Abgabe:
2012
Jahr der Verteidigung:
2012
Sprache(n) :
Englisch
Schlagworte:
Kv7, KCNQ channel opener, myography, Gracilis artery, intrapulmonary artery
DDC Klassifikation :
610 Medizin, Gesundheit
URN :
urn:nbn:de:gbv:28-diss2012-0095-9
Persistente URL:
http://purl.uni-rostock.de/rosdok/id00001056
erstellt am:
2012-10-29
zuletzt geändert am:
2018-06-30
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