zum Inhalt

 

Casalegno Garduño,  Rosaely

Expression of and immune responses to leukemia antigens in patients with hematological malignancies

Rostock : Universität , 2013

https://doi.org/10.18453/rosdok_id00001240

http://purl.uni-rostock.de/rosdok/id00001240

Abstract:

Leukemia cells are characterized by differentially expressed leukemia-associated antigens (LAAs). We wondered whether the expression of the LAAs WT1 and RHAMM as well as the T cellular immune response to these LAAs correlated with the clinical outcome of patients suffering from leukemia. We investigated the expression of WT1 and RHAMM at RNA level using qPCR before and after treatment. We concluded that WT1 is a suitable marker for MRD after allogeneic SCT and that a WT1-specific T cell response might contribute to the maintenance of CR.

Dissertation Open Access


Einrichtung :
Mathematisch-Naturwissenschaftliche Fakultät
Gutachter :
Schmitt,  Michael  (Prof. Dr. med.)
Schröder,  Reinhard  (Prof. Dr. rer. nat.)
Jahr der Abgabe:
2011
Jahr der Verteidigung:
2012
Sprache(n) :
Englisch
Schlagworte:
RHAMM, WT1, T cell response
DDC Klassifikation :
610 Medizin, Gesundheit
570 Biowissenschaften, Biologie
URN :
urn:nbn:de:gbv:28-diss2013-0153-1
Persistente URL:
http://purl.uni-rostock.de/rosdok/id00001240
erstellt am:
2013-11-01
zuletzt geändert am:
2018-06-30
Volltext