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John,  Lijo

Identification of host cellular requirements for positive strand RNA viruses  : Hepatitis C virus and hepatitis E virus

Rostock : Universität , 2013

https://doi.org/10.18453/rosdok_id00001246

http://purl.uni-rostock.de/rosdok/id00001246

Abstract:

Investigation of the host cellular requirements of two positive strand RNA viruses, by microarray, phospho-proteome array and by siRNA screening identified differential expression of host genes during hepatitis C virus viral entry. Also my studies suggest that NS4B regulates a newly identified oncogenic pathway. For hepatitis E virus, I looked for the cellular effects conferred by the capsid protein ORF2, and the results showed that ORF2 induced activation of CHOP did not lead to apoptosis which might be due to the up regulation of anti-apoptotic chaperones like Hsp72.

Dissertation Open Access


Einrichtung :
Mathematisch-Naturwissenschaftliche Fakultät
Gutachter :
Schaefer,  Stephan  (Prof. Dr. med.)
Bahl,  Hubert  (Prof. Dr. rer. nat.)
Jahr der Abgabe:
2011
Jahr der Verteidigung:
2011
Sprache(n) :
Englisch
Schlagworte:
microarray, NS4B, host factors hepatitis E virus, ORF2, ER stress, anti-apoptotic heat schock proteins
DDC Klassifikation :
570 Biowissenschaften, Biologie
URN :
urn:nbn:de:gbv:28-diss2013-0159-8
Persistente URL:
http://purl.uni-rostock.de/rosdok/id00001246
erstellt am:
2013-11-05
zuletzt geändert am:
2018-06-30
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