Schmitz,  Yvonne

Compartmental modelling of the Wnt pathway  : Elucidating the role of nucleo-cytoplasmic shuttling of beta-catenin and its antagonists

Rostock : Universität , 2014

https://doi.org/10.18453/rosdok_id00001303

http://purl.uni-rostock.de/rosdok/id00001303

The Wnt pathway plays a critical role in development and disease. The key player of the pathway is b-cat. In the nucleus, the complex formation of b-cat and TCF initiates target gene expression. Its activity is mainly regulated by retention and degradation by its antagonists APC, Axin and GSK3. Based on experimental findings, I develop and investigate compartmental models in order to analyse of the role of nucleo-cytoplasmic shuttling of these proteins in Wnt signalling. I show that the compartmental separation of b-cat and its antagonists yields an increase of the b-cat/TCF concentration.

Dissertation Open Access