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Schmitz,  Yvonne

Compartmental modelling of the Wnt pathway  : Elucidating the role of nucleo-cytoplasmic shuttling of beta-catenin and its antagonists

Rostock : Universität , 2014

https://doi.org/10.18453/rosdok_id00001303

http://purl.uni-rostock.de/rosdok/id00001303

The Wnt pathway plays a critical role in development and disease. The key player of the pathway is b-cat. In the nucleus, the complex formation of b-cat and TCF initiates target gene expression. Its activity is mainly regulated by retention and degradation by its antagonists APC, Axin and GSK3. Based on experimental findings, I develop and investigate compartmental models in order to analyse of the role of nucleo-cytoplasmic shuttling of these proteins in Wnt signalling. I show that the compartmental separation of b-cat and its antagonists yields an increase of the b-cat/TCF concentration.

Dissertation Open Access


Einrichtung :
Fakultät für Informatik und Elektrotechnik
Gutachter :
Wolkenhauer,  Olaf  (Prof. Dr.)
Uhrmacher,  Adelinde M.  (Prof. Dr. rer. nat. habil.)
Byrne,  Helen M.  (Prof. Dr.)
Jahr der Abgabe:
2013
Jahr der Verteidigung:
2013
Sprache(n) :
Englisch
Schlagworte:
Wnt pathway, intracellular transport, destruction complex, retention, steady state analysis, sensitivity analysis
DDC Klassifikation :
000 Allgemeines, Wissenschaft
500 Naturwissenschaften
URN :
urn:nbn:de:gbv:28-diss2014-0055-2
Persistente URL:
http://purl.uni-rostock.de/rosdok/id00001303
erstellt am:
2014-02-18
zuletzt geändert am:
2018-06-30
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