Compartmental modelling of the Wnt pathway : Elucidating the role of nucleo-cytoplasmic shuttling of beta-catenin and its antagonists

Yvonne Schmitz

doi:10.18453/rosdok_id00001303

Yvonne Schmitz

Compartmental modelling of the Wnt pathway : Elucidating the role of nucleo-cytoplasmic shuttling of beta-catenin and its antagonists

Universität Rostock, 2014

https://doi.org/10.18453/rosdok_id00001303

Abstract: The Wnt pathway plays a critical role in development and disease. The key player of the pathway is b-cat. In the nucleus, the complex formation of b-cat and TCF initiates target gene expression. Its activity is mainly regulated by retention and degradation by its antagonists APC, Axin and GSK3. Based on experimental findings, I develop and investigate compartmental models in order to analyse of the role of nucleo-cytoplasmic shuttling of these proteins in Wnt signalling. I show that the compartmental separation of b-cat and its antagonists yields an increase of the b-cat/TCF concentration.

Dissertation Freier Zugang

Titel:

Compartmental modelling of the Wnt pathway: Elucidating the role of nucleo-cytoplasmic shuttling of beta-catenin and its antagonists

Beteiligte Personen:

Yvonne Schmitz[VerfasserIn]
	1047564882
Olaf Wolkenhauer , Prof. Dr.[AkademischeR BetreuerIn]
	133515931
	Universität Rostock, Systembiologie und Bioinformatik, Institut für Informatik
Adelinde M. Uhrmacher , Prof. Dr. rer. nat. habil.[AkademischeR BetreuerIn]
	136258794
	Universität Rostock, Modellierung und Simulation, Institut für Informatik
Helen M. Byrne , Prof. Dr.[AkademischeR BetreuerIn]
	University of Oxford, Computational Biology, Mathematical Institute

Beteiligte Körperschaften:

Universität Rostock, Fakultät für Informatik und Elektrotechnik[Grad-verleihende Institution]
	10085032-7

Zusammenfassung:

The Wnt pathway plays a critical role in development and disease. The key player of the pathway is b-cat. In the nucleus, the complex formation of b-cat and TCF initiates target gene expression. Its activity is mainly regulated by retention and degradation by its antagonists APC, Axin and GSK3. Based on experimental findings, I develop and investigate compartmental models in order to analyse of the role of nucleo-cytoplasmic shuttling of these proteins in Wnt signalling. I show that the compartmental separation of b-cat and its antagonists yields an increase of the b-cat/TCF concentration. [Englisch]

Dokumenttyp:

Dissertation

Einrichtung:

Fakultät für Informatik und Elektrotechnik

Sprache:

Englisch

Sachgruppe der DNB:

000 Allgemeines, Wissenschaft

500 Naturwissenschaften

Veröffentlichung /
Entstehung:

Rostock: Universität Rostock

2014