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Mani,  Jiju

CD8+ T cell epitopes derived from the polyomavirus capsid protein VP1

Rostock : Universität , 2014

https://doi.org/10.18453/rosdok_id00001349

http://purl.uni-rostock.de/rosdok/id00001349

Abstract:

One method for treatment of JCV and BKV-related diseases is by adoptive transfer of virus-specific T-cells. Precursor frequency of JCV-capsid protein VP1-specific T-cells was very low compared to other viruses. Optimized assays revealed JCV-specific T cells with high avidity, peptide-specificity and high functional reactivity in long-term cultures. Additionally, novel, naturally processed JCV-VP1-derived CD8+ T cell epitopes were identified. These new data contribute to the development of therapies that, due to their cross-reactivity, target both polyomaviruses-related diseases simultaneously.

Dissertation Open Access


Einrichtung :
Mathematisch-Naturwissenschaftliche Fakultät
Gutachter :
Schmitt,  Michael  (Prof. Dr. med.)
Gimsa,  Ulrike  (apl. Prof. Dr. rer. nat. habil.)
Jahr der Abgabe:
2014
Jahr der Verteidigung:
2014
Sprache(n) :
Englisch
Schlagworte:
JCV, BKV, Immunotherapy
DDC Klassifikation :
570 Biowissenschaften, Biologie
URN :
urn:nbn:de:gbv:28-diss2014-0101-6
Persistente URL:
http://purl.uni-rostock.de/rosdok/id00001349
erstellt am:
2014-07-31
zuletzt geändert am:
2018-06-30
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