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Supe,  Linda

Design and synthesis of 1H-pyrazolo[3,4-b]pyridin-3(2H)-ones and corresponding N-nucleosides  : New purine isosters as potential drug-like scaffolds

Rostock : Universität , 2014

https://doi.org/10.18453/rosdok_id00001350

http://purl.uni-rostock.de/rosdok/id00001350

Abstract:

The work is devoted to study synthesis of 1H-pyrazolo[3,4-b]pyridin-3(2H)-ones with potential biological activity. 1H-pyrazolo[3,4-b]pyridin-3(2H)-one derived moieties were afforded using classical approaches involving [3+3] cyclocondensation of enamine fragment-containing heterocycle and bielectrophiles, inverse electron-demand Diels-Alder reaction, palladium-catalyzed C-C coupling reaction. N-nucleosides of purine analogues were synthesized using modified silyl Hilbert-Jones method. Scope and limitations of hydrogenation of pyridine ring of 1H-pyrazolo[3,4-b]pyridin-3(2H)-ones were studied.

Dissertation Open Access


Einrichtung :
Mathematisch-Naturwissenschaftliche Fakultät
Gutachter :
Schmidt,  Bernd  (Prof. Dr.)
Christoffers,  Jens  (Prof. Dr.)
Jahr der Abgabe:
2014
Jahr der Verteidigung:
2014
Sprache(n) :
Englisch
Schlagworte:
Deazapurines, Cyclocondensation, Fluorine
DDC Klassifikation :
540 Chemie
URN :
urn:nbn:de:gbv:28-diss2014-0102-2
Persistente URL:
http://purl.uni-rostock.de/rosdok/id00001350
erstellt am:
2014-07-31
zuletzt geändert am:
2018-06-30
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