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Strunz,  Sonja

Transcriptional responses to radiation exposure facilitate the discovery of biomarkers functioning as radiation biodosimeters

Rostock : Universität , 2014

https://doi.org/10.18453/rosdok_id00001384

http://purl.uni-rostock.de/rosdok/id00001384

The development of new methods for a retrospective quantification of the radiation dose of exposed individuals is of widespread interest. To this end, I developed a computational framework for biomarker discovery and radiation dose prediction and successfully identified gene signatures with which low and medium to high radiation doses can be accurately quantified. To enhance our understanding of the radiation-induced transcriptional response, I additionally analyzed microarray data of human PBLs after ex vivo gamma-irradiation and characterized affected functional processes and pathways.

Dissertation Open Access


Einrichtung :
Fakultät für Informatik und Elektrotechnik
Gutachter :
Wolkenhauer,  Olaf  (Prof. Dr.)
Kriehuber,  Ralf  (Dr.)
Stanke,  Mario  (Prof. Dr.)
Jahr der Abgabe:
2013
Jahr der Verteidigung:
2014
Sprache(n) :
Englisch
Schlagworte:
biodosimetry, Ionizing radiation, gene expression analysis, supervised classification
DDC Klassifikation :
000 Allgemeines, Wissenschaft
570 Biowissenschaften, Biologie
URN :
urn:nbn:de:gbv:28-diss2014-0136-2
Persistente URL:
http://purl.uni-rostock.de/rosdok/id00001384
erstellt am:
2014-09-03
zuletzt geändert am:
2018-06-30
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