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Wang,  Zi

The role of minimal nerve injury in a new animal model for CRPS

Rostock : Universität , 2014

https://doi.org/10.18453/rosdok_id00001409

http://purl.uni-rostock.de/rosdok/id00001409

Abstract:

Complex regional pain syndrome(CRPS) is a chronic neuropathic pain disease which typically develops in distal extremities after trauma. The mechanism of CRPS is still unknown. We combined a closed soft tissue trauma in the hindlimb of a rat and a minimal nerve injury in the ipsilateral sciatic nerve to establish a new animal model for CRPS. This model induced CRPS symptoms including pain, altered temperature, muscle edema, regional inflammation and muscle cell apoptosis. However, most of the symptoms disappeared within four weeks. This new model is not sufficient to induce an ongoing CRPS.

Dissertation Open Access


Einrichtung :
Universitätsmedizin
Gutachter :
Vollmar,  Brigitte  (Prof. Dr. med.)
Gradl,  Georg  (Universität Rostock, Abteilung für Unfall- und Wiederherstellungschirurgie)
Kayser,  Ralph  (PD. Dr. med.)
Jahr der Abgabe:
2012
Jahr der Verteidigung:
2013
Sprache(n) :
Englisch
Schlagworte:
complex regional pain syndrome, closed soft tissue trauma, post traumatic pain
DDC Klassifikation :
610 Medizin, Gesundheit
URN :
urn:nbn:de:gbv:28-diss2014-0161-0
Persistente URL:
http://purl.uni-rostock.de/rosdok/id00001409
erstellt am:
2014-09-15
zuletzt geändert am:
2018-06-30
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