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Salem,  Tareq

Gene mutations and losses of heterozygosity of TP53 and PTEN in colorectal cancer

Rostock : Universität , 2014

https://doi.org/10.18453/rosdok_id00001422

http://purl.uni-rostock.de/rosdok/id00001422

Abstract:

This study was conducted to find out if the patterns of PTEN gene molecular aberration in colorectal carcinoma are consistent with the classic molecular features ascribed to a tumour suppressor gene. PTEN gene mutations and LOH were assayed in a series of 18 colorectal carcinomas. Three PTEN gene mutations were found in 1 tumour, complete loss of one allele(LOH)in 2 tumours and allelic imbalance (AI) in 6 tumours. LOH or AI did not target the 1 tumour with the PTEN gene mutations. The widely held belief of PTEN as a classical tumour suppressor gene is not supported by the findings from this study.

Dissertation Open Access


Einrichtung :
Universitätsmedizin
Gutachter :
Prall,  Friedrich  (Prof. Dr. med)
Linnebacher,  Michael  (PD Dr. rer. nat.)
Evert,  Mathias  (Prof. Dr. med.)
Jahr der Abgabe:
2014
Jahr der Verteidigung:
2014
Sprache(n) :
Englisch
Schlagworte:
tumur Xeno-grafts/primary tumour cell lines, PTEN expression, tumour suppressor gene inactivation
DDC Klassifikation :
610 Medizin, Gesundheit
URN :
urn:nbn:de:gbv:28-diss2014-0174-3
Persistente URL:
http://purl.uni-rostock.de/rosdok/id00001422
erstellt am:
2014-11-11
zuletzt geändert am:
2018-06-30
Volltext