The role of gap junctional intercellular communication and connexins in the differentiation of human neural progenitor cells

Heiko Lemcke

doi:10.18453/rosdok_id00001457

Heiko Lemcke

The role of gap junctional intercellular communication and connexins in the differentiation of human neural progenitor cells

Universität Rostock, 2015

https://doi.org/10.18453/rosdok_id00001457

Abstract: Our findings provide a dual function of connexin43 (Cx43) and gap junctional intercellular communication (GJIC) in the neural development of human progenitor cells. 1) GJIC accompanied by high Cx43 expression is necessary to maintain cells in a proliferative state by mediating the mitogenic effects of growth factors. 2) GJIC is required to complete neuronal differentiation, including the establishment of a neural network. However, uncoupling of cells is crucial in the early stage of differentiation during cell fate commitment. Further, we showed that Cx43 regulates neuronal cell-fate.

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Titel:

The role of gap junctional intercellular communication and connexins in the differentiation of human neural progenitor cells

Beteiligte Personen:

Heiko Lemcke[VerfasserIn]
	1049755472
Sergei Kuznetsov , Dr. rer. nat.[AkademischeR BetreuerIn]
	Universität Rostock, Institut für Biowissenschaften, Abteilung Tierphysiologie
Arndt Rolfs , Prof. Dr. med.[AkademischeR BetreuerIn]
	136256864
	Universität Rostock, Universitätsmedizin, Albrecht Kossel Institut für Neuroregeneration

Beteiligte Körperschaften:

Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät[Grad-verleihende Institution]
	2147083-2

Zusammenfassung:

Our findings provide a dual function of connexin43 (Cx43) and gap junctional intercellular communication (GJIC) in the neural development of human progenitor cells. 1) GJIC accompanied by high Cx43 expression is necessary to maintain cells in a proliferative state by mediating the mitogenic effects of growth factors. 2) GJIC is required to complete neuronal differentiation, including the establishment of a neural network. However, uncoupling of cells is crucial in the early stage of differentiation during cell fate commitment. Further, we showed that Cx43 regulates neuronal cell-fate. [Englisch]

Dokumenttyp:

Dissertation

Einrichtung:

Mathematisch-Naturwissenschaftliche Fakultät

Sprache:

Englisch

Sachgruppe der DNB:

610 Medizin, Gesundheit

570 Biowissenschaften, Biologie

Veröffentlichung /
Entstehung:

Rostock

Rostock: Universität Rostock