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Thamilarasan,  Madhan

MicroRNA and messengerRNA expression changes during interferon-beta and glatiramer acetate treatment in peripheral blood cells of multiple sclerosis patients

Rostock : Universität , 2015

https://doi.org/10.18453/rosdok_id00001548

http://purl.uni-rostock.de/rosdok/id00001548

Abstract:

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system. There are many types of disease-modifying drugs available but none of them can cure MS. The studies reported in this thesis analyzed the changes which happen at the transcriptome level during the course of treatment with glatiramer acetate (GA) and interferon-beta-1b. The studies reported revealed several differentially expressed transcripts which included both mRNAs and microRNAs. These can be considered as biomarkers for therapy monitoring and help to better understand the mechanisms of action of the drugs.

Dissertation Open Access


Einrichtung :
Universitätsmedizin
Gutachter :
Zettl,  Uwe  (Prof. Dr. med.)
Paul,  Friedemann  (Prof. Dr. med.)
Faiss,  Jürgen  (Dr. med.)
Jahr der Abgabe:
2014
Jahr der Verteidigung:
2015
Sprache(n) :
Englisch
Schlagworte:
neuroimmunology, immunomodulatory treatment, gene expression profiling
DDC Klassifikation :
610 Medizin, Gesundheit
570 Biowissenschaften, Biologie
URN :
urn:nbn:de:gbv:28-diss2015-0098-2
Persistente URL:
http://purl.uni-rostock.de/rosdok/id00001548
erstellt am:
2015-06-08
zuletzt geändert am:
2018-06-30
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