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Ludwig,  Marion

The regenerative potential of the CD117+AT2R stimulated cell population in vitro and in vivo

Rostock : Universität , 2015

https://doi.org/10.18453/rosdok_id00001596

http://purl.uni-rostock.de/rosdok/id00001596

Abstract:

Regarding innovative therapeutical approaches for cardiac regeneration, we thoroughly investigated CD117+ and CD117+AT2R stimulated murine bone marrow stem cells. Electrophysiological measurements and in vitro results indicated the differentiation into an endothelial-like phenotype excluding a previously discussed development into cardiomyocytes. Cell implantation into infarcted murine heart provoked a significant improvement of cardiac function. AT2R triggered effects were not significantly different and should be analyzed in interplay with its opposing receptor AT1.

Dissertation Open Access


Einrichtung :
Mathematisch-Naturwissenschaftliche Fakultät
Gutachter :
Steinhoff,  Gustav  (Prof. Dr. med.)
Gimsa,  Ulrike  (Prof. Dr. rer. nat.)
Martin,  Ulrich  (Prof. Dr. rer. nat.)
Jahr der Abgabe:
2014
Jahr der Verteidigung:
2015
Sprache(n) :
Englisch
übersetzter Titel :
Das regenerative Potential der CD117+AT2R stimulierten Zellpopulation in vitro und in vivo
Schlagworte:
CD117+ stem cells, transient AT2R stimulation, cardiac stem cell therapy, vasculogenesis, cardioprotection
DDC Klassifikation :
610 Medizin, Gesundheit
URN :
urn:nbn:de:gbv:28-diss2015-0146-3
Persistente URL:
http://purl.uni-rostock.de/rosdok/id00001596
erstellt am:
2015-08-19
zuletzt geändert am:
2018-06-30
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