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Asghari,  Farahnaz

Molecular, immunological and genetic studies on murine autoimmune pancreatitis

Rostock : Universität , 2015

https://doi.org/10.18453/rosdok_id00001639

http://purl.uni-rostock.de/rosdok/id00001639

Abstract:

To identify susceptible regions of the genome(quantitative trait loci; QTLs)controlling Autoimmune pancreatitis in a mouse model of the disease, we established an advanced intercross line originating from three inbred mouse strains: MRL/MpJ,BXD2,NZM and wild derived strain Cast. The fourth generation of outbred intercross mice was characterized phenotypically by scoring histopathological changes of the pancreas and genotyped (Illumina, USA).Five QTLs, regulating the severity of AIP, were identified, which mapped to chromosomes 2,4,5 and 6(with Logarithmic P values varied from 3.2 to 5.4).

Dissertation Open Access


Einrichtung :
Mathematisch-Naturwissenschaftliche Fakultät
Gutachter :
Jaster,  Robert  (Prof. Dr. med.)
Gimsa,  Ulrike  (Prof. Dr.)
Jahr der Abgabe:
2015
Jahr der Verteidigung:
2015
Sprache(n) :
Englisch
Schlagworte:
Autoimmune Pankreatitis, quantitative trait loci, MRL/MpJ Mouse
DDC Klassifikation :
610 Medizin, Gesundheit
570 Biowissenschaften, Biologie
URN :
urn:nbn:de:gbv:28-diss2015-0189-6
Persistente URL:
http://purl.uni-rostock.de/rosdok/id00001639
erstellt am:
2015-12-07
zuletzt geändert am:
2018-06-30
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