Sprache(n) : |
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übersetzter Titel
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Bioinformatic analysis of immunomodulatory processes in LEW.1AR1-iddm rats - an animal model for autoimmune diabetes |
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übersetzte Zusammenfassung
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The LEW.1AR1-iddm rat animal model develops a autoimmune diabetes (T1DM) with beta cell destruction. Aim of this study: Investigation of predictive potential of gene expression profiling in peripheral blood and tolerance-inducing effects through treatment by the modulating antibody RIB5/2 in the prediabetic period. Results were, inflammatory gene expression profiles in PBMCs may serve as surrogate markers for different stages of islet inflammation in T1DM. Diabetes preventing antibody RIB5/2 treatment could induce tolerance against beta cell autoimmunity with specific gene signatures in blood. |
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Schlagworte: |
Diabetes, Medizin, Prädiktion, Prävention, Antikörper, Tiermodell |
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DDC Klassifikation : |
570 Biowissenschaften, Biologie |
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