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Delyagina,  Evgenya

Magnetic nanoparticle-based gene delivery  : mechanisms and clinical perspectives

Rostock : Universität , 2017

https://doi.org/10.18453/rosdok_id00001874

http://purl.uni-rostock.de/rosdok/id00001874

Abstract:

The development of safe and efficient gene delivery systems is the key to the overall success of gene therapy. This work introduced a MNP-based nonviral gene delivery approach for transfection in clinically relevant cells. Moreover, the in vitro mechanism studies could explained the beneficial properties of the proposed carrier design. This work demonstrated, that proposed system could efficiently and safely transfect human bone marrow derived mesenchymal stem cells. Additionaly, the clinical perspectives of MNP-based gene therapy were discussed and evaluated in this dissertation.

Dissertation Open Access


Einrichtung :
Universitätsmedizin
Gutachter :
Steinhoff,  Gustav  (Prof. Dr. med.)
Pützer,  Brigitte M.  (Prof. Dr. med. Dr. rer. nat.)
Zenke,  Martin  (Prof. Dr. rer. nat.)
Jahr der Abgabe:
2016
Jahr der Verteidigung:
2017
Sprache(n) :
Englisch
übersetzter Titel :
Magnetische Nanopartikel-basierter Gentransfer :
Mechanismen und Klinische Perspektiven
Schlagworte:
nonviral transfection, magnetic nanoparticles, human mesenchymal stem cells, polyethylenimine
DDC Klassifikation :
610 Medizin, Gesundheit
URN :
urn:nbn:de:gbv:28-diss2017-0038-4
Persistente URL:
http://purl.uni-rostock.de/rosdok/id00001874
erstellt am:
2017-03-27
zuletzt geändert am:
2018-06-30
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