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Hieke,  Cathleen

Oral bacteria, stem cells and neutrophils in vitro  : a model for periodontal infection

Rostock : Universität , 2017

https://doi.org/10.18453/rosdok_id00001941

http://purl.uni-rostock.de/rosdok/id00001941

Abstract:

Periodontitis is a chronic inflammatory disease induced by bacteria from oral biofilms. Bacteria interact with host cells and can subsequently provoke activation of polymorphonuclear neutrophils (PMNs). In this study, an in vitro model was applied to investigate interactions between periodontal pathogens, i.e., P. intermedia, T. forsythia and P. gingivalis, human dental stem cells (hDFSCs) and PMNs. HDFSCs modulate immune activity of PMNs after infection with oral bacteria implying general suitability of hDFSCs in tissue regeneration strategies after tissue damage in periodontal infections.

Dissertation Open Access


Einrichtung :
Mathematisch-Naturwissenschaftliche Fakultät
Gutachter :
Kreikemeyer,  Bernd  (Prof. Dr. rer. nat.)
Bahl,  Hubert  (Prof. Dr. rer. nat.)
Jahr der Abgabe:
2017
Jahr der Verteidigung:
2017
Sprache(n) :
Englisch
Schlagworte:
microbial-host interaction, peptidylarginine deiminase, immune modulation, antimicrobial activity
DDC Klassifikation :
570 Biowissenschaften, Biologie
URN :
urn:nbn:de:gbv:28-diss2017-0105-5
Persistente URL:
http://purl.uni-rostock.de/rosdok/id00001941
erstellt am:
2017-07-19
zuletzt geändert am:
2018-06-30
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