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Pügge,  Johanna

Adhesive mechanisms of histone-induced neutrophil-endothelium interactions in the muscle microcirculation

Rostock : Universität , 2017

https://doi.org/10.18453/rosdok_id00002004

http://purl.uni-rostock.de/rosdok/id00002004

Abstract:

Intravital microscopy of the mouse cremaster microcirculation was used to examine the role of specific adhesion molecules in histone-dependent leukocyte recruitment. Histones type 3 were given locally to the cremaster muscle sack and specific adhesion molecules were blocked by systemic administration of monoclonal antibodies. Extracellular histones 3 induced leukocyte recruitment in a dose-dependent manner. Histone-induced neutrophil rolling is predominately mediated by P-selectin/PSGL-1 interactions, whereas histone-induced leukocyte adhesion is inter alia mediated by Mac-1 and LFA-1.

Dissertation Open Access


Einrichtung :
Universitätsmedizin
Gutachter :
Vollmar,  Brigitte  (Prof. Dr. med.)
Thorlacius,  Henrik  (Prof. Dr. med.)
Klar,  Ernst  (Prof. Dr. med.)
Jahr der Abgabe:
2016
Jahr der Verteidigung:
2017
Sprache(n) :
Englisch
Schlagworte:
selectin, integrin, inflammation, histone type 3
DDC Klassifikation :
610 Medizin, Gesundheit
URN :
urn:nbn:de:gbv:28-diss2017-0168-6
Persistente URL:
http://purl.uni-rostock.de/rosdok/id00002004
erstellt am:
2017-12-20
zuletzt geändert am:
2018-06-30
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