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Dauben,  Thomas Josef

Establishment of a novel in vitro implant infection model  : effects of electrical stimulation on staphylococci using alternating current

Rostock : Universität , 2018

https://doi.org/10.18453/rosdok_id00002037

http://purl.uni-rostock.de/rosdok/id00002037

Abstract:

An in vitro system for electrical stimulation of cells and bacteria was developed. Stimulation of cells and bacteria can be conducted under similar conditions. Prior to experiments, numerical simulations were performed. Methods for evaluation of effects were established. Stimulation showed significant effects on bacterial growth and biofilm mass production. Following stimulation, changes in extracellular DNA amounts were detected. In co-culture, stimulation led to increased CFU/ml S. epidermidis in supernatants, on and into MG63 cells on electrode surfaces and chamber bottom.

Dissertation Open Access


Einrichtung :
Mathematisch-Naturwissenschaftliche Fakultät
Gutachter :
Kreikemeyer,  Bernd  (Prof. Dr. rer. nat.)
Bahl,  Hubert  (Prof. Dr. rer. nat.)
Bader,  Rainer  (Prof. Dr. med.)
Jahr der Abgabe:
2017
Jahr der Verteidigung:
2018
Sprache(n) :
Englisch
Schlagworte:
biofilm, osteoblast, bacterial growth
DDC Klassifikation :
570 Biowissenschaften, Biologie
URN :
urn:nbn:de:gbv:28-diss2018-0031-8
Persistente URL:
http://purl.uni-rostock.de/rosdok/id00002037
erstellt am:
2018-03-21
zuletzt geändert am:
2018-06-30
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