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Schwartz,  Margit

Effect of cannabidiol on disease-associated functions of human vascular smooth muscle cells  : role of the anti-oxidative enzyme heme oxygenase-1

Rostock : Universität , 2018

https://doi.org/10.18453/rosdok_id00002522

http://purl.uni-rostock.de/rosdok/id00002522

Excessive proliferation and migration of VSMC are closely linked to cardiovascular diseases and cancer. The enzyme HO-1 was shown to be involved in anti-proliferative/anti-migratory effects in VSMC. This thesis investigates the effect of CBD on VSMC and HO-1. HO-1 was significantly increased by CBD in an ROS-depentent manner. In addition, inhibition of proliferation and migration of VSMC were observed and not attenuated by inhibition/knockdown of HO-1. This work provides evidence of a CBD-mediated induction of HO-1 in VSMC and potential protective effects via an HO-1-independent mechanism.

Dissertation Open Access


Einrichtung :
Universitätsmedizin
Gutachter :
Hinz,  Burkhard
Rauch,  Bernhard
Kraft,  Karin
Sprache(n) :
Englisch
DDC Klassifikation :
570 Biowissenschaften, Biologie
610 Medizin, Gesundheit
URN :
urn:nbn:de:gbv:28-rosdok_id00002522-0
Persistente URL:
http://purl.uni-rostock.de/rosdok/id00002522
erstellt am:
2019-08-21
zuletzt geändert am:
2019-08-21
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