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Sadraddin,  Haval Lutfalla

Antiarrhythmic effect of human bone marrow-dereived CD271+ mesenchymal stem cells tested in vivo using a new infarction-re-infarction mouse model

Rostock : Universität , 2019

https://doi.org/10.18453/rosdok_id00002970

http://purl.uni-rostock.de/rosdok/id00002970

Abstract:

This experiment showed the safety and antiarrhythmic effect of human bone marrow-derived CD271+ MSC. This was performed in immune deficient mice (Rag2-/-γc-/--mice) with electrocardiogram monitoring through Implantation of telemtry system. The induction of ventricular arrhythmias has been achieved via a permanent re-infarction through left anterior descending artery (LAD) ligation one week after a 30-minute ischemia-reperfusion. The time between 2 infarctions gave the stem cells the required period to entgraft themselves after their intramyocardial injection with the first infarction.

Dissertation Open Access


Einrichtung :
Universitätsmedizin
Gutachter :
Stamm,  Christof
Steinhoff,  Gustav
Vollmar,  Brigitte
Sprache(n) :
Englisch
DDC Klassifikation :
610 Medizin, Gesundheit
URN :
urn:nbn:de:gbv:28-rosdok_id00002970-5
Persistente URL:
http://purl.uni-rostock.de/rosdok/id00002970
erstellt am:
2021-03-04
zuletzt geändert am:
2021-03-04
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