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Sharma,  Arpna

Stressors modulating granulosa cell functionality, ovulation and oocyte competence in bovines

Rostock : Universität , 2020

https://doi.org/10.18453/rosdok_id00002985

http://purl.uni-rostock.de/rosdok/id00002985

Abstract:

Ovarian follicles are exposed to stressors such as higher levels of non-esterified free fatty acids (NEFAs) or hypoxia. High follicular levels of NEFA severely affect granulosa cells (GCs) by targeting key genes of estradiol biosynthesis. Cultured GCs exposed to hypoxia showed specific regulation of genes that initiate luteinization. These effects were partly mediated by hypoxia inducible factor1 (HIF1). Thus, ovarian follicles are susceptible to elevated NEFA levels, but cope up with severe hypoxia prevailing during late folliculogenesis through specific transcription factors such as HIF1.

Dissertation Open Access


Einrichtung :
Andere Einrichtungen
Gutachter :
Braun,  Beate
Pfarrer,  Christiane
Vanselow,  Jens
Sprache(n) :
Englisch
DDC Klassifikation :
570 Biowissenschaften, Biologie
URN :
urn:nbn:de:gbv:28-rosdok_id00002985-6
Persistente URL:
http://purl.uni-rostock.de/rosdok/id00002985
erstellt am:
2021-03-24
zuletzt geändert am:
2021-03-24
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