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Shang,  Yuru

Immunoglobulin G mediates chemoresistance to oxaliplatin in colon cancer cells by inhibiting the ERK signal transduction pathway

Rostock : Universität , 2021

https://doi.org/10.18453/rosdok_id00003037

http://purl.uni-rostock.de/rosdok/id00003037

Abstract:

The aim of this study was to investigate the effect of therapeutically used immunoglobulin G (IgG) on colon cancer in the presence of oxaliplatin. We observed that IgG failed to significantly influence tumor cell viability and tumor growth; however, it significantly inhibited the cytotoxic activity of oxaliplatin in vitro. In addition, we observed that oxaliplatin-induced the activation of ERK; however, IgG inhibits ERK activity. This implies that the application of therapeutical IgG to treating patients, which are receiving oxaliplatin, might have harmful side effects.

Dissertation Open Access


Einrichtung :
Universitätsmedizin
Gutachter :
Zechner,  Dietmar
Wiegering,  Armin
Linnebacher,  Michael
Sprache(n) :
Englisch
DDC Klassifikation :
570 Biowissenschaften, Biologie
610 Medizin, Gesundheit
URN :
urn:nbn:de:gbv:28-rosdok_id00003037-4
Persistente URL:
http://purl.uni-rostock.de/rosdok/id00003037
erstellt am:
2021-06-03
zuletzt geändert am:
2021-06-03
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