New Aspects in Homogeneous Hydrogenation – Development of Practical Rhodium Phosphine Catalysts and Environmentally Benign Iron Catalysts

10.18453/rosdok_id00000282 Enthaler, Stephan Stephan Enthaler http://d-nb.info/gnd/134197402 New Aspects in Homogeneous Hydrogenation – Development of Practical Rhodium Phosphine Catalysts and Environmentally Benign Iron Catalysts Universität Rostock 2007 540 Chemistry & allied sciences 2007 en http://purl.uni-rostock.de/rosdok/id00000282 urn:nbn:de:gbv:28-diss2008-0008-7 This dissertation deals with the application of monodentate phosphine ligands in asymmetric hydrogenation of C-C double bonds. The usefulness of rhodium catalysts containing phosphines based on the 4,5-Dihydro-3H-dinaphtho[2,1-c;1´,2´-e]phosphepine scaffold was demonstrated in the reduction of various prochiral substrates, since excellent enantioselectivities up to 96% ee were achieved. Furthermore, the properties of iron-based catalysts were studied in the field of transfer hydrogenation. Here high catalyst activities up to 2500 h-1 were obtained in the reduction of ketones.