mycoreobjectrosdok_disshab_0000000263rosdok_disshab_0000000263rosdokdisshabrosdok_derivate_00000039372023-08-08T10:01:02.171Z2009-07-15T14:17:14.686Zadministratorpublished1rosdok_derivate_0000003937truetruederivate_types:fulltextVolltextfulltextwf_edit_epub wf_register_epubstate:publishedstate:publishedveröffentlichtpublishedrosdok/id00000502604745575MODS updated during RosDok migration in June 2021DissertationHochschulschrift138627258MarineHovakimyan1977-VerfasserInautIn vitro and in vivo characterization of neural progenitor cells as putative candidates for experimental studies and clinical trials in cell replacement therapy for neurodegenerative diseasesenProf. Dr. med.OliverSchmittAkademischeR BetreuerIndgsProf. Dr. rer.Dieter G.WeissAkademischeR BetreuerIndgsProf. Dr. med. vet.IngoNolteAkademischeR BetreuerIndgs2147083-2Universität RostockMathematisch-Naturwissenschaftliche FakultätGrad-verleihende Institutiondgg10.18453/rosdok_id00000502http://purl.uni-rostock.de/rosdok/id00000502urn:nbn:de:gbv:28-diss2009-0119-0570 Biowissenschaften, BiologieMathematisch-Naturwissenschaftliche Fakultätfrei zugänglich (Open Access)Lizenz Metadaten: CC0Nutzungsrechte erteiltalle Rechte vorbehaltenUniversität RostockRostock2008monographic20092008Universitätsbibliothek RostockRostock20092009Fetal conditionally immortalized striatal cells ST14A and human mesencephalic neural progenitor cells (NPCs) were studied with respect to proliferation and differentiation in in vitro experiments. In in vivo experiments, human NPCs were investigated after transplantation into neonatal and adult hemiparkinsonian rat striatum. The survival, migration and dopaminergic (DAergic) differentiation of human NPCs in the host brain was investigated. Improvement in lesion-induced motor impairment has been demonstrated in both groups of hemiparkinsonian rats, independently from DA-ergic differentiation.In der vorliegenden Arbeit wurden fetale immortalisierte Zellen der Linie ST14 A und humane mesenzephale Progenitorzellen (NPC) in vitro untersucht. In in vivo-Experimenten wurden die humanen NPC nach Transplantation in das Striatum neonataler oder adulter Heminparkinson-Ratten untersucht. In diesen Transplantationsstudien lag der Hauptaspekt auf dem Überleben, der Migration und der dopaminergen Differenzierung der humanen NPC im Wirtsgewebe. Eine Verbesserung des motorischen Verhaltens konnte in beiden Transplantationsmodellen gezeigt werden, unabhängig von dopaminerger Differenzierung.Parkinson's diseaseStem cellsCentral nervous systemNeurorestorationParkinson KrankheitStammzellenZentrales NervensystemUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00000502doctype:epubdoctype:epubDokumenttypDocument typedoctype:epub.dissertationdoctype:epub.dissertationDissertationdoctoral thesisdiniPublType:doctoralThesis diniPublType2022:PhDThesis XMetaDissPlusThesisLevel:thesis.doctoralinfo:eu-repo/semantics/doctoralThesisdocumentnatureOfContent:ppn_105825778natureOfContent:ppn_105825778HochschulschriftdiniPublType2022:DoctoralThesisdiniPublType2022:DoctoralThesisDissertation oder HabilitationDoctoral thesisDRIVERdiniPublType2022:PhDThesisdiniPublType2022:PhDThesisDissertationPhD thesisKDSF (Pu34)XMetaDissPlusThesisLevel:thesis.doctoralXMetaDissPlusThesisLevel:thesis.doctoralDoktorarbeitdoctoral thesisrfc5646:enrfc5646:enEnglischEnglishengengSDNB:570SDNB:570570 Biowissenschaften, Biologie570 Life scienceinstitution:unirostockinstitution:unirostockUniversität RostockUniversity of RostockUniversität RostockUniversität RostockUni.Rostockhttp://d-nb.info/gnd/38329-6institution:unirostock.mnfinstitution:unirostock.mnfMathematisch-Naturwissenschaftliche FakultätFaculty of Mathematics and Natural SciencesUniversität Rostock. Mathematisch-Naturwissenschaftliche FakultätMathematisch-Natur-<br />wissenschaftliche FakultätUni.Rostock.Fakultaet.MNFhttp://d-nb.info/gnd/2147083-2accesscondition:openaccessaccesscondition:openaccessfrei zugänglich (Open Access)open accesshttp://purl.org/coar/access_right/c_abf2OAfreeinfo:eu-repo/semantics/openAccess[DE-28]Open Access$gControlled Vocabulary for Access Rights$uhttp://purl.org/coar/access_right/c_abf2licenseinfo:metadatalicenseinfo:metadataLizenzen für Metadatenlicenseinfo:metadata.cc0licenseinfo:metadata.cc0Lizenz Metadaten: CC0license metadata: CC0/creativecommons/p/zero/1.0/88x31.pnghttps://creativecommons.org/publicdomain/zero/1.0/licenseinfo:depositlicenseinfo:depositVeröffentlichungsgenehmigungpermission to storelicenseinfo:deposit.rightsgrantedlicenseinfo:deposit.rightsgrantedNutzungsrechte erteiltrights grantedlicenseinfo:worklicenseinfo:workWerkworklicenseinfo:work.rightsreservedlicenseinfo:work.rightsreservedalle Rechte vorbehaltenall rights reserved/creativecommons/r/reserved/0.9/88x31.png[DE-28]Urheberrechtsschutz 1.0$gRights Statements$uhttp://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/In vitro and in vivo characterization of neural progenitor cells as putative candidates for experimental studies and clinical trials in cell replacement therapy for neurodegenerative diseasesIn vitro and in vivo characterization of neural progenitor cells as putative candidates for experimental studies and clinical trials in cell replacement therapy for neurodegenerative diseasesgnd:138627258gnd:2147083-2gnd:138627258gnd:2147083-2rosdok_disshab_0000000263-d608657e39gnd:138627258Marine HovakimyanMarine Hovakimyanrosdok_disshab_0000000263-d608657e60Prof. Dr. med. Oliver SchmittProf. Dr. med. Oliver Schmittrosdok_disshab_0000000263-d608657e72Prof. Dr. rer. Dieter G. WeissProf. Dr. rer. Dieter G. Weissrosdok_disshab_0000000263-d608657e84Prof. Dr. med. vet. Ingo NolteProf. Dr. med. vet. Ingo Nolterosdok_disshab_0000000263-d608657e97gnd:2147083-2Universität Rostock Mathematisch-Naturwissenschaftliche FakultätUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätMarine HovakimyanProf. Dr. med. Oliver SchmittProf. Dr. rer. Dieter G. WeissProf. Dr. med. vet. Ingo NolteUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätMarine HovakimyanProf. Dr. med. Oliver SchmittProf. Dr. rer. Dieter G. WeissProf. Dr. med. vet. Ingo NolteUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätMarine HovakimyanRostockUniversität Rostockepub.dissertation10.18453/rosdok_id00000502http://purl.uni-rostock.de/rosdok/id00000502urn:nbn:de:gbv:28-diss2009-0119-0Parkinson's diseaseStem cellsCentral nervous systemNeurorestorationParkinson KrankheitStammzellenZentrales NervensystemFetal conditionally immortalized striatal cells ST14A and human mesencephalic neural progenitor cells (NPCs) were studied with respect to proliferation and differentiation in in vitro experiments. In in vivo experiments, human NPCs were investigated after transplantation into neonatal and adult hemiparkinsonian rat striatum. The survival, migration and dopaminergic (DAergic) differentiation of human NPCs in the host brain was investigated. Improvement in lesion-induced motor impairment has been demonstrated in both groups of hemiparkinsonian rats, independently from DA-ergic differentiation.In der vorliegenden Arbeit wurden fetale immortalisierte Zellen der Linie ST14 A und humane mesenzephale Progenitorzellen (NPC) in vitro untersucht. In in vivo-Experimenten wurden die humanen NPC nach Transplantation in das Striatum neonataler oder adulter Heminparkinson-Ratten untersucht. In diesen Transplantationsstudien lag der Hauptaspekt auf dem Überleben, der Migration und der dopaminergen Differenzierung der humanen NPC im Wirtsgewebe. Eine Verbesserung des motorischen Verhaltens konnte in beiden Transplantationsmodellen gezeigt werden, unabhängig von dopaminerger Differenzierung.20082008epub.dissertation1 Dissertation_Hovakimyan_2009.pdf 2932731 9cf32add6b57c9b13e3cda31a70007ea rosdok/id00000502604745575MODS updated during RosDok migration in June 2021DissertationHochschulschrift138627258MarineHovakimyan1977-VerfasserInautIn vitro and in vivo characterization of neural progenitor cells as putative candidates for experimental studies and clinical trials in cell replacement therapy for neurodegenerative diseasesenProf. Dr. med.OliverSchmittAkademischeR BetreuerIndgsProf. Dr. rer.Dieter G.WeissAkademischeR BetreuerIndgsProf. Dr. med. vet.IngoNolteAkademischeR BetreuerIndgs2147083-2Universität RostockMathematisch-Naturwissenschaftliche FakultätGrad-verleihende Institutiondgg10.18453/rosdok_id00000502http://purl.uni-rostock.de/rosdok/id00000502urn:nbn:de:gbv:28-diss2009-0119-0570 Biowissenschaften, BiologieMathematisch-Naturwissenschaftliche Fakultätfrei zugänglich (Open Access)Lizenz Metadaten: CC0Nutzungsrechte erteiltalle Rechte vorbehaltenUniversität RostockRostock2008monographic20092008Universitätsbibliothek RostockRostock20092009Fetal conditionally immortalized striatal cells ST14A and human mesencephalic neural progenitor cells (NPCs) were studied with respect to proliferation and differentiation in in vitro experiments. In in vivo experiments, human NPCs were investigated after transplantation into neonatal and adult hemiparkinsonian rat striatum. The survival, migration and dopaminergic (DAergic) differentiation of human NPCs in the host brain was investigated. Improvement in lesion-induced motor impairment has been demonstrated in both groups of hemiparkinsonian rats, independently from DA-ergic differentiation.In der vorliegenden Arbeit wurden fetale immortalisierte Zellen der Linie ST14 A und humane mesenzephale Progenitorzellen (NPC) in vitro untersucht. In in vivo-Experimenten wurden die humanen NPC nach Transplantation in das Striatum neonataler oder adulter Heminparkinson-Ratten untersucht. In diesen Transplantationsstudien lag der Hauptaspekt auf dem Überleben, der Migration und der dopaminergen Differenzierung der humanen NPC im Wirtsgewebe. Eine Verbesserung des motorischen Verhaltens konnte in beiden Transplantationsmodellen gezeigt werden, unabhängig von dopaminerger Differenzierung.Parkinson's diseaseStem cellsCentral nervous systemNeurorestorationParkinson KrankheitStammzellenZentrales NervensystemUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00000502 2009-07-15T14:17:14.686Z 2023-08-08T10:01:02.171Z 2023-08-18T10:01:02.175Z {"identifier":"rosdok/id00000502","type":"local_id","additional":"","service":"MCRLocalID","created":"2018-06-30T12:39:01.178Z"} {"identifier":"http://purl.uni-rostock.de/rosdok/id00000502","type":"purl","additional":"","service":"RosDokPURL","created":"2018-06-30T12:39:01.375Z","registered":"2018-06-30T12:39:01.375Z"} {"identifier":"10.18453/rosdok_id00000502","type":"doi","additional":"","service":"RosDokDOI","created":"2018-06-30T12:39:02.784Z","registered":"2018-06-30T12:39:02.784Z"} {"identifier":"urn:nbn:de:gbv:28-diss2009-0119-0","type":"dnbUrn","additional":"","service":"RosDokURN","created":"2018-06-30T12:39:01.182Z","registered":"2009-07-22T02:25:49.273Z"} administratorfulltextfile/rosdok_disshab_0000000263/rosdok_derivate_0000003937/Dissertation_Hovakimyan_2009.pdfIn vitro and in vivo characterization of neural progenitor cells as putative candidates for experimental studies and clinical trials in cell replacement therapy for neurodegenerative diseasesIn vitro and in vivo characterization of neural progenitor cells as putative candidates for experimental studies and clinical trials in cell replacement therapy for neurodegenerative diseasesgnd:138627258gnd:2147083-2gnd:138627258gnd:2147083-2rosdok_disshab_0000000263-d608657e39gnd:138627258Marine HovakimyanMarine Hovakimyanrosdok_disshab_0000000263-d608657e60Prof. Dr. med. Oliver SchmittProf. Dr. med. Oliver Schmittrosdok_disshab_0000000263-d608657e72Prof. Dr. rer. Dieter G. WeissProf. Dr. rer. Dieter G. Weissrosdok_disshab_0000000263-d608657e84Prof. Dr. med. vet. Ingo NolteProf. Dr. med. vet. Ingo Nolterosdok_disshab_0000000263-d608657e97gnd:2147083-2Universität Rostock Mathematisch-Naturwissenschaftliche FakultätUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätMarine HovakimyanProf. Dr. med. Oliver SchmittProf. Dr. rer. Dieter G. WeissProf. Dr. med. vet. Ingo NolteUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätMarine HovakimyanProf. Dr. med. Oliver SchmittProf. Dr. rer. Dieter G. WeissProf. Dr. med. vet. Ingo NolteUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätMarine HovakimyanRostockUniversität Rostockepub.dissertation10.18453/rosdok_id00000502http://purl.uni-rostock.de/rosdok/id00000502urn:nbn:de:gbv:28-diss2009-0119-0Parkinson's diseaseStem cellsCentral nervous systemNeurorestorationParkinson KrankheitStammzellenZentrales NervensystemFetal conditionally immortalized striatal cells ST14A and human mesencephalic neural progenitor cells (NPCs) were studied with respect to proliferation and differentiation in in vitro experiments. In in vivo experiments, human NPCs were investigated after transplantation into neonatal and adult hemiparkinsonian rat striatum. The survival, migration and dopaminergic (DAergic) differentiation of human NPCs in the host brain was investigated. Improvement in lesion-induced motor impairment has been demonstrated in both groups of hemiparkinsonian rats, independently from DA-ergic differentiation.In der vorliegenden Arbeit wurden fetale immortalisierte Zellen der Linie ST14 A und humane mesenzephale Progenitorzellen (NPC) in vitro untersucht. In in vivo-Experimenten wurden die humanen NPC nach Transplantation in das Striatum neonataler oder adulter Heminparkinson-Ratten untersucht. In diesen Transplantationsstudien lag der Hauptaspekt auf dem Überleben, der Migration und der dopaminergen Differenzierung der humanen NPC im Wirtsgewebe. Eine Verbesserung des motorischen Verhaltens konnte in beiden Transplantationsmodellen gezeigt werden, unabhängig von dopaminerger Differenzierung.20082008[xslt]Saxonrosdok/id00000502https://purl.uni-rostock.de/rosdok/id0000050260474557510.18453/rosdok_id00000502urn:nbn:de:gbv:28-diss2009-0119-0Marine HovakimyanHovakimyan MarineIn vitro and in vivo characterization of neural progenitor cells as putative candidates for experimental studies and clinical trials in cell replacement therapy for neurodegenerative diseasesDissertationdoctoral thesisUniversität Rostock, 2008Fetal conditionally immortalized striatal cells ST14A and human mesencephalic neural progenitor cells (NPCs) were studied with respect to proliferation and differentiation in in vitro experiments. In in vivo experiments, human NPCs were investigated after transplantation into neonatal and adult…Marine HovakimyanIn vitro and in vivo characterization of neural progenitor cells as putative candidates for experimental studies and clinical trials in cell replacement therapy for neurodegenerative diseasesUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00000502138627258MarineHovakimyan1977-VerfasserInautProf. Dr. med.OliverSchmittAkademischeR BetreuerIndgsProf. Dr. rer.Dieter G.WeissAkademischeR BetreuerIndgsProf. Dr. med. vet.IngoNolteAkademischeR BetreuerIndgs2147083-2Universität RostockMathematisch-Naturwissenschaftliche FakultätGrad-verleihende Institutiondgg[doi]10.18453/rosdok_id00000502[purl]http://purl.uni-rostock.de/rosdok/id00000502[urn]urn:nbn:de:gbv:28-diss2009-0119-0open_access20082008epoch:21th_centuryrfc5646:endoctype:epub.dissertationaccesscondition:openaccessSDNB:570institution:unirostock.mnfstate:published