Die Mutation des mitochondrialen ATP8 Gens verbessert den hepatischen Energiestatus im murinen Modell des akuten septischen Leberversagens

10.18453/rosdok_id00000675 Hildebrandt, Anke Anke Hildebrandt http://d-nb.info/gnd/141580720 Die Mutation des mitochondrialen ATP8 Gens verbessert den hepatischen Energiestatus im murinen Modell des akuten septischen Leberversagens Universität Rostock 2009 610 Medical sciences Medicine 2009 de http://purl.uni-rostock.de/rosdok/id00000675 urn:nbn:de:gbv:28-diss2010-0091-5 We investigated whether a mutation in the ATPase subunit-8 gene exerts effects on the course of endotoxemic acute liver failure in mice. Wildtype and ATP8 mutant mice were challenged with D-galactosamine and E. coli lipopolysaccharide and studied 6 hrs thereafter. Induction of endotoxemic liver failure provoked marked liver damage, a drop of total adenosine nucleotide level and an increased malondialdehyde production. In contrast, ATP levels in livers ATP8 mutants remained significantly higher. As a net result, ATP8 mutant mice showed lower transaminase release and better survival rate.