mycoreobjectrosdok_disshab_0000000587rosdok_disshab_0000000587rosdokdisshabrosdok_derivate_00000045992023-08-08T10:02:23.306Z2011-03-10T11:58:07.455Zadministratorpublished1rosdok_derivate_0000004599truetruederivate_types:fulltextVolltextfulltextwf_edit_epub wf_register_epubstate:publishedstate:publishedveröffentlichtpublishedrosdok/id0000079268840362XMODS updated during RosDok migration in June 2021DissertationHochschulschrift143723146Anne-CarolineSchmöle1983-VerfasserInautNovel small molecules as GSK-3β inhibitors in human neural progenitor cellsenProf. Dr.ArndtRolfsAkademischeR BetreuerIndgsProf. Dr.MatthiasBellerAkademischeR BetreuerIndgsPD Dr.SergeiKuznetsovAkademischeR BetreuerIndgsProf. Dr.JohannesSchwarzAkademischeR BetreuerIndgs2147083-2Universität RostockMathematisch-Naturwissenschaftliche FakultätGrad-verleihende Institutiondgg10.18453/rosdok_id00000792http://purl.uni-rostock.de/rosdok/id00000792urn:nbn:de:gbv:28-diss2011-0014-9570 Biowissenschaften, BiologieMathematisch-Naturwissenschaftliche Fakultätfrei zugänglich (Open Access)Lizenz Metadaten: CC0Nutzungsrechte erteiltalle Rechte vorbehaltenUniversität RostockRostock2010monographic20112010Universitätsbibliothek RostockRostock20112011GSK-3β as the key enzyme of Wnt/β-catenin pathway is involved in various processes during the neuronal differentiation of stem and progenitor cells. Therefore small molecules are of great interest as they might provide new pharmacological tools to influence and study underlying mechanism. Thus, we developed a multi-level screening system to identify novel GSK-3β inhibitors. The influence on Wnt/β-catenin signaling was evaluated in human neural progenitor cells. New compounds raised the neuronal differentiation, whereat it was shown that the effect was due antagonistic action at GSK-3β.GSK-3Wntneurale VorläuferzellenUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00000792doctype:epubdoctype:epubDokumenttypDocument typedoctype:epub.dissertationdoctype:epub.dissertationDissertationdoctoral thesisdiniPublType:doctoralThesis diniPublType2022:PhDThesis XMetaDissPlusThesisLevel:thesis.doctoralinfo:eu-repo/semantics/doctoralThesisdocumentnatureOfContent:ppn_105825778natureOfContent:ppn_105825778HochschulschriftdiniPublType2022:DoctoralThesisdiniPublType2022:DoctoralThesisDissertation oder HabilitationDoctoral thesisDRIVERdiniPublType2022:PhDThesisdiniPublType2022:PhDThesisDissertationPhD thesisKDSF (Pu34)XMetaDissPlusThesisLevel:thesis.doctoralXMetaDissPlusThesisLevel:thesis.doctoralDoktorarbeitdoctoral thesisrfc5646:enrfc5646:enEnglischEnglishengengSDNB:570SDNB:570570 Biowissenschaften, Biologie570 Life scienceinstitution:unirostockinstitution:unirostockUniversität RostockUniversity of RostockUniversität RostockUniversität RostockUni.Rostockhttp://d-nb.info/gnd/38329-6institution:unirostock.mnfinstitution:unirostock.mnfMathematisch-Naturwissenschaftliche FakultätFaculty of Mathematics and Natural SciencesUniversität Rostock. 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Therefore small molecules are of great interest as they might provide new pharmacological tools to influence and study underlying mechanism. Thus, we developed a multi-level screening system to identify novel GSK-3β inhibitors. The influence on Wnt/β-catenin signaling was evaluated in human neural progenitor cells. 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Therefore small molecules are of great interest as they might provide new pharmacological tools to influence and study underlying mechanism. Thus, we developed a multi-level screening system to identify novel GSK-3β inhibitors. The influence on Wnt/β-catenin signaling was evaluated in human neural progenitor cells. New compounds raised the neuronal differentiation, whereat it was shown that the effect was due antagonistic action at GSK-3β.20102010[xslt]Saxonrosdok/id00000792https://purl.uni-rostock.de/rosdok/id0000079268840362X10.18453/rosdok_id00000792urn:nbn:de:gbv:28-diss2011-0014-9Anne-Caroline SchmöleSchmöle Anne-CarolineNovel small molecules as GSK-3β inhibitors in human neural progenitor cellsDissertationdoctoral thesisUniversität Rostock, 2010GSK-3β as the key enzyme of Wnt/β-catenin pathway is involved in various processes during the neuronal differentiation of stem and progenitor cells. Therefore small molecules are of great interest as they might provide new pharmacological tools to influence and study underlying mechanism. Thus, we…Anne-Caroline SchmöleNovel small molecules as GSK-3β inhibitors in human neural progenitor cellsUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00000792143723146Anne-CarolineSchmöle1983-VerfasserInautProf. Dr.ArndtRolfsAkademischeR BetreuerIndgsProf. Dr.MatthiasBellerAkademischeR BetreuerIndgsPD Dr.SergeiKuznetsovAkademischeR BetreuerIndgsProf. Dr.JohannesSchwarzAkademischeR BetreuerIndgs2147083-2Universität RostockMathematisch-Naturwissenschaftliche FakultätGrad-verleihende Institutiondgg[doi]10.18453/rosdok_id00000792[purl]http://purl.uni-rostock.de/rosdok/id00000792[urn]urn:nbn:de:gbv:28-diss2011-0014-9open_access20102010epoch:21th_centuryrfc5646:endoctype:epub.dissertationaccesscondition:openaccessSDNB:570institution:unirostock.mnfstate:published