mycoreobjectrosdok_disshab_0000000592rosdok_disshab_0000000592rosdokdisshabrosdok_derivate_00000045432023-08-08T10:02:25.005Z2012-03-13T10:07:22.406Zadministratorpublished1rosdok_derivate_0000004543truetruederivate_types:fulltextVolltextfulltextwf_edit_epub wf_register_epubstate:publishedstate:publishedveröffentlichtpublishedrosdok/id00000797688394019MODS updated during RosDok migration in June 2021DissertationHochschulschrift14332196XDevangPatel1981-VerfasserInautAnnexin A1 as a new functional linker between actin filaments and phagosomes during phagocytosisenPD Dr.SergeiA. KuznetsovAkademischeR BetreuerIndgsProf. Dr.GarethGriffithsAkademischeR BetreuerIndgs2147083-2Universität RostockMathematisch-Naturwissenschaftliche FakultätGrad-verleihende Institutiondgg10.18453/rosdok_id00000797http://purl.uni-rostock.de/rosdok/id00000797urn:nbn:de:gbv:28-diss2011-0019-0570 Biowissenschaften, BiologieMathematisch-Naturwissenschaftliche Fakultätfrei zugänglich (Open Access)Lizenz Metadaten: CC0Nutzungsrechte erteiltalle Rechte vorbehaltenUniversität RostockRostock2010monographic20112010Universitätsbibliothek RostockRostock20122012In the current study annexin A1 was identified as a factor, which binds to latex beads phagosomes (LBP) and facilitates F-actin-LBP interaction in vitro. In macrophages the association of endogenous annexin A1 with LBP membranes is strongly correlated with F-actin accumulation at the LBP. Furthermore, it showed that receptor signalling influenced annexin A1 recruitment on different LBP. Reduction of annexin A1 expression resulted in impaired phagocytosis and actin flashing. These data revealed that annexin A1 as an important component of opsonic phagocytosis.receptor signallingactin flashingopsonic receptorsF-actincalciumUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00000797doctype:epubdoctype:epubDokumenttypDocument typedoctype:epub.dissertationdoctype:epub.dissertationDissertationdoctoral thesisdiniPublType:doctoralThesis diniPublType2022:PhDThesis XMetaDissPlusThesisLevel:thesis.doctoralinfo:eu-repo/semantics/doctoralThesisdocumentnatureOfContent:ppn_105825778natureOfContent:ppn_105825778HochschulschriftdiniPublType2022:DoctoralThesisdiniPublType2022:DoctoralThesisDissertation oder HabilitationDoctoral thesisDRIVERdiniPublType2022:PhDThesisdiniPublType2022:PhDThesisDissertationPhD thesisKDSF (Pu34)XMetaDissPlusThesisLevel:thesis.doctoralXMetaDissPlusThesisLevel:thesis.doctoralDoktorarbeitdoctoral thesisrfc5646:enrfc5646:enEnglischEnglishengengSDNB:570SDNB:570570 Biowissenschaften, Biologie570 Life scienceinstitution:unirostockinstitution:unirostockUniversität RostockUniversity of RostockUniversität RostockUniversität RostockUni.Rostockhttp://d-nb.info/gnd/38329-6institution:unirostock.mnfinstitution:unirostock.mnfMathematisch-Naturwissenschaftliche FakultätFaculty of Mathematics and Natural SciencesUniversität Rostock. Mathematisch-Naturwissenschaftliche FakultätMathematisch-Natur-<br />wissenschaftliche FakultätUni.Rostock.Fakultaet.MNFhttp://d-nb.info/gnd/2147083-2accesscondition:openaccessaccesscondition:openaccessfrei zugänglich (Open Access)open accesshttp://purl.org/coar/access_right/c_abf2OAfreeinfo:eu-repo/semantics/openAccess[DE-28]Open Access$gControlled Vocabulary for Access Rights$uhttp://purl.org/coar/access_right/c_abf2licenseinfo:metadatalicenseinfo:metadataLizenzen für Metadatenlicenseinfo:metadata.cc0licenseinfo:metadata.cc0Lizenz Metadaten: CC0license metadata: CC0/creativecommons/p/zero/1.0/88x31.pnghttps://creativecommons.org/publicdomain/zero/1.0/licenseinfo:depositlicenseinfo:depositVeröffentlichungsgenehmigungpermission to storelicenseinfo:deposit.rightsgrantedlicenseinfo:deposit.rightsgrantedNutzungsrechte erteiltrights grantedlicenseinfo:worklicenseinfo:workWerkworklicenseinfo:work.rightsreservedlicenseinfo:work.rightsreservedalle Rechte vorbehaltenall rights reserved/creativecommons/r/reserved/0.9/88x31.png[DE-28]Urheberrechtsschutz 1.0$gRights Statements$uhttp://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/Annexin A1 as a new functional linker between actin filaments and phagosomes during phagocytosisAnnexin A1 as a new functional linker between actin filaments and phagosomes during phagocytosisgnd:14332196Xgnd:2147083-2gnd:14332196Xgnd:2147083-2rosdok_disshab_0000000592-d491042e39gnd:14332196XDevang PatelDevang Patelrosdok_disshab_0000000592-d491042e60PD Dr. Sergei A. KuznetsovPD Dr. Sergei A. Kuznetsovrosdok_disshab_0000000592-d491042e72Prof. Dr. Gareth GriffithsProf. Dr. Gareth Griffithsrosdok_disshab_0000000592-d491042e84gnd:2147083-2Universität Rostock Mathematisch-Naturwissenschaftliche FakultätUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätDevang PatelPD Dr. Sergei A. KuznetsovProf. Dr. Gareth GriffithsUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätDevang PatelPD Dr. Sergei A. KuznetsovProf. Dr. Gareth GriffithsUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätDevang PatelRostockUniversität Rostockepub.dissertation10.18453/rosdok_id00000797http://purl.uni-rostock.de/rosdok/id00000797urn:nbn:de:gbv:28-diss2011-0019-0receptor signallingactin flashingopsonic receptorsF-actincalciumIn the current study annexin A1 was identified as a factor, which binds to latex beads phagosomes (LBP) and facilitates F-actin-LBP interaction in vitro. In macrophages the association of endogenous annexin A1 with LBP membranes is strongly correlated with F-actin accumulation at the LBP. Furthermore, it showed that receptor signalling influenced annexin A1 recruitment on different LBP. Reduction of annexin A1 expression resulted in impaired phagocytosis and actin flashing. These data revealed that annexin A1 as an important component of opsonic phagocytosis.20102010epub.dissertation1 Dissertation_Patel_2011.pdf 2999780 c69a554ad7504f2727ea61e2c46a381c rosdok/id00000797688394019MODS updated during RosDok migration in June 2021DissertationHochschulschrift14332196XDevangPatel1981-VerfasserInautAnnexin A1 as a new functional linker between actin filaments and phagosomes during phagocytosisenPD Dr.SergeiA. KuznetsovAkademischeR BetreuerIndgsProf. Dr.GarethGriffithsAkademischeR BetreuerIndgs2147083-2Universität RostockMathematisch-Naturwissenschaftliche FakultätGrad-verleihende Institutiondgg10.18453/rosdok_id00000797http://purl.uni-rostock.de/rosdok/id00000797urn:nbn:de:gbv:28-diss2011-0019-0570 Biowissenschaften, BiologieMathematisch-Naturwissenschaftliche Fakultätfrei zugänglich (Open Access)Lizenz Metadaten: CC0Nutzungsrechte erteiltalle Rechte vorbehaltenUniversität RostockRostock2010monographic20112010Universitätsbibliothek RostockRostock20122012In the current study annexin A1 was identified as a factor, which binds to latex beads phagosomes (LBP) and facilitates F-actin-LBP interaction in vitro. In macrophages the association of endogenous annexin A1 with LBP membranes is strongly correlated with F-actin accumulation at the LBP. Furthermore, it showed that receptor signalling influenced annexin A1 recruitment on different LBP. Reduction of annexin A1 expression resulted in impaired phagocytosis and actin flashing. These data revealed that annexin A1 as an important component of opsonic phagocytosis.receptor signallingactin flashingopsonic receptorsF-actincalciumUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00000797 2012-03-13T10:07:22.406Z 2023-08-08T10:02:25.005Z 2023-08-18T10:02:25.009Z {"identifier":"rosdok/id00000797","type":"local_id","additional":"","service":"MCRLocalID","created":"2018-06-30T12:49:41.299Z"} {"identifier":"http://purl.uni-rostock.de/rosdok/id00000797","type":"purl","additional":"","service":"RosDokPURL","created":"2018-06-30T12:49:41.472Z","registered":"2018-06-30T12:49:41.472Z"} {"identifier":"10.18453/rosdok_id00000797","type":"doi","additional":"","service":"RosDokDOI","created":"2018-06-30T12:49:42.762Z","registered":"2018-06-30T12:49:42.762Z"} {"identifier":"urn:nbn:de:gbv:28-diss2011-0019-0","type":"dnbUrn","additional":"","service":"RosDokURN","created":"2018-06-30T12:49:41.304Z","registered":"2012-03-14T03:26:57.680Z"} administratorfulltextfile/rosdok_disshab_0000000592/rosdok_derivate_0000004543/Dissertation_Patel_2011.pdfAnnexin A1 as a new functional linker between actin filaments and phagosomes during phagocytosisAnnexin A1 as a new functional linker between actin filaments and phagosomes during phagocytosisgnd:14332196Xgnd:2147083-2gnd:14332196Xgnd:2147083-2rosdok_disshab_0000000592-d491042e39gnd:14332196XDevang PatelDevang Patelrosdok_disshab_0000000592-d491042e60PD Dr. Sergei A. KuznetsovPD Dr. Sergei A. Kuznetsovrosdok_disshab_0000000592-d491042e72Prof. Dr. Gareth GriffithsProf. Dr. Gareth Griffithsrosdok_disshab_0000000592-d491042e84gnd:2147083-2Universität Rostock Mathematisch-Naturwissenschaftliche FakultätUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätDevang PatelPD Dr. Sergei A. KuznetsovProf. Dr. Gareth GriffithsUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätDevang PatelPD Dr. Sergei A. KuznetsovProf. Dr. Gareth GriffithsUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätDevang PatelRostockUniversität Rostockepub.dissertation10.18453/rosdok_id00000797http://purl.uni-rostock.de/rosdok/id00000797urn:nbn:de:gbv:28-diss2011-0019-0receptor signallingactin flashingopsonic receptorsF-actincalciumIn the current study annexin A1 was identified as a factor, which binds to latex beads phagosomes (LBP) and facilitates F-actin-LBP interaction in vitro. In macrophages the association of endogenous annexin A1 with LBP membranes is strongly correlated with F-actin accumulation at the LBP. Furthermore, it showed that receptor signalling influenced annexin A1 recruitment on different LBP. Reduction of annexin A1 expression resulted in impaired phagocytosis and actin flashing. These data revealed that annexin A1 as an important component of opsonic phagocytosis.20102010[xslt]Saxonrosdok/id00000797https://purl.uni-rostock.de/rosdok/id0000079768839401910.18453/rosdok_id00000797urn:nbn:de:gbv:28-diss2011-0019-0Devang PatelPatel DevangAnnexin A1 as a new functional linker between actin filaments and phagosomes during phagocytosisDissertationdoctoral thesisUniversität Rostock, 2010In the current study annexin A1 was identified as a factor, which binds to latex beads phagosomes (LBP) and facilitates F-actin-LBP interaction in vitro. In macrophages the association of endogenous annexin A1 with LBP membranes is strongly correlated with F-actin accumulation at the LBP.…Devang PatelAnnexin A1 as a new functional linker between actin filaments and phagosomes during phagocytosisUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id0000079714332196XDevangPatel1981-VerfasserInautPD Dr.SergeiA. KuznetsovAkademischeR BetreuerIndgsProf. Dr.GarethGriffithsAkademischeR BetreuerIndgs2147083-2Universität RostockMathematisch-Naturwissenschaftliche FakultätGrad-verleihende Institutiondgg[doi]10.18453/rosdok_id00000797[purl]http://purl.uni-rostock.de/rosdok/id00000797[urn]urn:nbn:de:gbv:28-diss2011-0019-0open_access20102010epoch:21th_centuryrfc5646:endoctype:epub.dissertationaccesscondition:openaccessSDNB:570institution:unirostock.mnfstate:published