mycoreobjectrosdok_disshab_0000000643rosdok_disshab_0000000643rosdokdisshabrosdok_derivate_00000046082023-08-08T10:02:36.855Z2011-05-13T16:07:04.239Zadministratorpublished1rosdok_derivate_0000004608truetruederivate_types:fulltextVolltextfulltextwf_edit_epub wf_register_epubstate:publishedstate:publishedveröffentlichtpublishedrosdok/id00000844658204726MODS updated during RosDok migration in June 2021DissertationHochschulschrift1011739771WeiweiWang1979-VerfasserInautPolymer mediated gene delivery for adult stem cell therapyPolymervermittelter Gentransfer für die Therapie mit adulten StammzellenenProf. Dr. med.GustavSteinhoffAkademischeR BetreuerIndgsProf. Dr. rer. nat.Dieter G.WeissAkademischeR BetreuerIndgsProf. Dr. rer. nat.DorisKleeAkademischeR BetreuerIndgs2147083-2Universität RostockMathematisch-Naturwissenschaftliche FakultätGrad-verleihende Institutiondgg10.18453/rosdok_id00000844http://purl.uni-rostock.de/rosdok/id00000844urn:nbn:de:gbv:28-diss2011-0070-9610 Medizin, GesundheitMathematisch-Naturwissenschaftliche Fakultätfrei zugänglich (Open Access)Lizenz Metadaten: CC0Nutzungsrechte erteiltalle Rechte vorbehaltenUniversität RostockRostock2010monographic20112010Universitätsbibliothek RostockRostock20112011Polymer mediated gene delivery was studied and utilized in adult stem cell therapy. The gene expression of human mesenchymal stem cells (MSCs) could be significantly enhanced by polyethylenimine (PEI) mediated gene delivery. The tumor cell growth could be effectively inhibited both in vitro and in vivo by delivering antisense oligonucleotide with non-viral method. 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Gustav SteinhoffProf. Dr. med. Gustav Steinhoffrosdok_disshab_0000000643-d2417320e74Prof. Dr. rer. nat. Dieter G. WeissProf. Dr. rer. nat. Dieter G. Weissrosdok_disshab_0000000643-d2417320e87Prof. Dr. rer. nat. Doris KleeProf. Dr. rer. nat. Doris Kleerosdok_disshab_0000000643-d2417320e99gnd:2147083-2Universität Rostock Mathematisch-Naturwissenschaftliche FakultätUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätWeiwei WangProf. Dr. med. Gustav SteinhoffProf. Dr. rer. nat. Dieter G. WeissProf. Dr. rer. nat. Doris KleeUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätWeiwei WangProf. Dr. med. Gustav SteinhoffProf. Dr. rer. nat. Dieter G. WeissProf. Dr. rer. nat. Doris KleeUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätWeiwei WangRostockUniversität Rostockepub.dissertation10.18453/rosdok_id00000844http://purl.uni-rostock.de/rosdok/id00000844urn:nbn:de:gbv:28-diss2011-0070-9polyethyleniminenon-viral gene therapygene activated substratestem cell recruitmentmesenchymal stem cellsPolymer mediated gene delivery was studied and utilized in adult stem cell therapy. The gene expression of human mesenchymal stem cells (MSCs) could be significantly enhanced by polyethylenimine (PEI) mediated gene delivery. The tumor cell growth could be effectively inhibited both in vitro and in vivo by delivering antisense oligonucleotide with non-viral method. Furthermore, gene activated substrate (GAS) prepared in this study could allow localized gene delivery, sustained gene release, high transfection efficiency, low cytotoxicity and high potential for stem cell recruitment.20102010epub.dissertation1 Dissertation_Wang_2011.pdf 4481463 29f5535156558d8ea33de859706823d1 rosdok/id00000844658204726MODS updated during RosDok migration in June 2021DissertationHochschulschrift1011739771WeiweiWang1979-VerfasserInautPolymer mediated gene delivery for adult stem cell therapyPolymervermittelter Gentransfer für die Therapie mit adulten StammzellenenProf. Dr. med.GustavSteinhoffAkademischeR BetreuerIndgsProf. Dr. rer. nat.Dieter G.WeissAkademischeR BetreuerIndgsProf. Dr. rer. nat.DorisKleeAkademischeR BetreuerIndgs2147083-2Universität RostockMathematisch-Naturwissenschaftliche FakultätGrad-verleihende Institutiondgg10.18453/rosdok_id00000844http://purl.uni-rostock.de/rosdok/id00000844urn:nbn:de:gbv:28-diss2011-0070-9610 Medizin, GesundheitMathematisch-Naturwissenschaftliche Fakultätfrei zugänglich (Open Access)Lizenz Metadaten: CC0Nutzungsrechte erteiltalle Rechte vorbehaltenUniversität RostockRostock2010monographic20112010Universitätsbibliothek RostockRostock20112011Polymer mediated gene delivery was studied and utilized in adult stem cell therapy. 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Gustav SteinhoffProf. Dr. med. Gustav Steinhoffrosdok_disshab_0000000643-d2417320e74Prof. Dr. rer. nat. Dieter G. WeissProf. Dr. rer. nat. Dieter G. Weissrosdok_disshab_0000000643-d2417320e87Prof. Dr. rer. nat. Doris KleeProf. Dr. rer. nat. Doris Kleerosdok_disshab_0000000643-d2417320e99gnd:2147083-2Universität Rostock Mathematisch-Naturwissenschaftliche FakultätUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätWeiwei WangProf. Dr. med. Gustav SteinhoffProf. Dr. rer. nat. Dieter G. WeissProf. Dr. rer. nat. Doris KleeUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätWeiwei WangProf. Dr. med. Gustav SteinhoffProf. Dr. rer. nat. Dieter G. WeissProf. Dr. rer. nat. Doris KleeUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätWeiwei WangRostockUniversität Rostockepub.dissertation10.18453/rosdok_id00000844http://purl.uni-rostock.de/rosdok/id00000844urn:nbn:de:gbv:28-diss2011-0070-9polyethyleniminenon-viral gene therapygene activated substratestem cell recruitmentmesenchymal stem cellsPolymer mediated gene delivery was studied and utilized in adult stem cell therapy. The gene expression of human mesenchymal stem cells (MSCs) could be significantly enhanced by polyethylenimine (PEI) mediated gene delivery. The tumor cell growth could be effectively inhibited both in vitro and in vivo by delivering antisense oligonucleotide with non-viral method. Furthermore, gene activated substrate (GAS) prepared in this study could allow localized gene delivery, sustained gene release, high transfection efficiency, low cytotoxicity and high potential for stem cell recruitment.20102010[xslt]Saxonrosdok/id00000844https://purl.uni-rostock.de/rosdok/id0000084465820472610.18453/rosdok_id00000844urn:nbn:de:gbv:28-diss2011-0070-9Weiwei WangWang WeiweiPolymer mediated gene delivery for adult stem cell therapyDissertationdoctoral thesisUniversität Rostock, 2010Polymer mediated gene delivery was studied and utilized in adult stem cell therapy. The gene expression of human mesenchymal stem cells (MSCs) could be significantly enhanced by polyethylenimine (PEI) mediated gene delivery. The tumor cell growth could be effectively inhibited both in vitro and in…Weiwei WangPolymer mediated gene delivery for adult stem cell therapyPolymervermittelter Gentransfer für die Therapie mit adulten StammzellenUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id000008441011739771WeiweiWang1979-VerfasserInautProf. Dr. med.GustavSteinhoffAkademischeR BetreuerIndgsProf. Dr. rer. nat.Dieter G.WeissAkademischeR BetreuerIndgsProf. Dr. rer. nat.DorisKleeAkademischeR BetreuerIndgs2147083-2Universität RostockMathematisch-Naturwissenschaftliche FakultätGrad-verleihende Institutiondgg[doi]10.18453/rosdok_id00000844[purl]http://purl.uni-rostock.de/rosdok/id00000844[urn]urn:nbn:de:gbv:28-diss2011-0070-9open_access20102010epoch:21th_centuryrfc5646:endoctype:epub.dissertationaccesscondition:openaccessSDNB:610institution:unirostock.mnfstate:published