mycoreobjectrosdok_disshab_0000000708rosdok_disshab_0000000708rosdokdisshabrosdok_derivate_00000046972023-08-08T10:02:52.928Z2011-11-10T09:49:42.244Zadministratorpublished1rosdok_derivate_0000004697truetruederivate_types:fulltextVolltextfulltextwf_edit_epub wf_register_epubstate:publishedstate:publishedveröffentlichtpublishedrosdok/id00000904671886061MODS updated during RosDok migration in June 2021DissertationHochschulschrift1014828619SimoneFrey1980-VerfasserInautA systems biology approach to dynamic modelling of the AMP-activated kinase pathwayenProf. (PhD)OlafWolkenhauerAkademischeR BetreuerIndgsProf. Dr.UrsulaKummerAkademischeR BetreuerIndgsProf. Dr.MattiasGoksörAkademischeR BetreuerIndgs10085032-7Universität RostockFakultät für Informatik und ElektrotechnikGrad-verleihende Institutiondgg10.18453/rosdok_id00000904http://purl.uni-rostock.de/rosdok/id00000904urn:nbn:de:gbv:28-diss2011-0135-1570 Biowissenschaften, BiologieFakultät für Informatik und Elektrotechnikfrei zugänglich (Open Access)Lizenz Metadaten: CC0Nutzungsrechte erteiltalle Rechte vorbehaltenUniversität RostockRostock2011monographic20112011Universitätsbibliothek RostockRostock20112011A systems biology approach is used to investigate a key regulator of energy sensing, the AMPK/ Snf1 pathway. Therefore, a stimulus is derived considering transmembrane glucose transport. Fluorescent microscopy data of Mig1, a Snf1 pathway component, were processed through a mathematical approach. The data were compared to simulations of alternative network structures suggested to underlie the Snf1 pathway. Certain structures could be excluded. Besides, applying quantitative measures showed that the design of a MAPK pathway is favourable for the transmission of fast signals with short duration.transductionSnf1 pathwayquantitative measuresfluorescent microscopysaccharomyces cerevisiaeUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00000904doctype:epubdoctype:epubDokumenttypDocument typedoctype:epub.dissertationdoctype:epub.dissertationDissertationdoctoral thesisdiniPublType:doctoralThesis diniPublType2022:PhDThesis XMetaDissPlusThesisLevel:thesis.doctoralinfo:eu-repo/semantics/doctoralThesisdocumentnatureOfContent:ppn_105825778natureOfContent:ppn_105825778HochschulschriftdiniPublType2022:DoctoralThesisdiniPublType2022:DoctoralThesisDissertation oder HabilitationDoctoral thesisDRIVERdiniPublType2022:PhDThesisdiniPublType2022:PhDThesisDissertationPhD thesisKDSF (Pu34)XMetaDissPlusThesisLevel:thesis.doctoralXMetaDissPlusThesisLevel:thesis.doctoralDoktorarbeitdoctoral thesisrfc5646:enrfc5646:enEnglischEnglishengengSDNB:570SDNB:570570 Biowissenschaften, Biologie570 Life scienceinstitution:unirostockinstitution:unirostockUniversität RostockUniversity of RostockUniversität RostockUniversität RostockUni.Rostockhttp://d-nb.info/gnd/38329-6institution:unirostock.iefinstitution:unirostock.iefFakultät für Informatik und ElektrotechnikFaculty of Computer Science and Electrical EngineeringUniversität Rostock. 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Therefore, a stimulus is derived considering transmembrane glucose transport. Fluorescent microscopy data of Mig1, a Snf1 pathway component, were processed through a mathematical approach. The data were compared to simulations of alternative network structures suggested to underlie the Snf1 pathway. Certain structures could be excluded. 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Therefore, a stimulus is derived considering transmembrane glucose transport. Fluorescent microscopy data of Mig1, a Snf1 pathway component, were processed through a mathematical approach. The data were compared to simulations of alternative network structures suggested to underlie the Snf1 pathway. Certain structures could be excluded. Besides, applying quantitative measures showed that the design of a MAPK pathway is favourable for the transmission of fast signals with short duration.20112011[xslt]Saxonrosdok/id00000904https://purl.uni-rostock.de/rosdok/id0000090467188606110.18453/rosdok_id00000904urn:nbn:de:gbv:28-diss2011-0135-1Simone FreyFrey SimoneA systems biology approach to dynamic modelling of the AMP-activated kinase pathwayDissertationdoctoral thesisUniversität Rostock, 2011A systems biology approach is used to investigate a key regulator of energy sensing, the AMPK/ Snf1 pathway. Therefore, a stimulus is derived considering transmembrane glucose transport. 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