10.18453/rosdok_id00000904
Frey, Simone
Simone
Frey
http://d-nb.info/gnd/1014828619
A systems biology approach to dynamic modelling of the AMP-activated kinase pathway
Universität Rostock
2011
570 Life science
2011
en
http://purl.uni-rostock.de/rosdok/id00000904
urn:nbn:de:gbv:28-diss2011-0135-1
A systems biology approach is used to investigate a key regulator of energy sensing, the AMPK/ Snf1 pathway. Therefore, a stimulus is derived considering transmembrane glucose transport. Fluorescent microscopy data of Mig1, a Snf1 pathway component, were processed through a mathematical approach. The data were compared to simulations of alternative network structures suggested to underlie the Snf1 pathway. Certain structures could be excluded. Besides, applying quantitative measures showed that the design of a MAPK pathway is favourable for the transmission of fast signals with short duration.