mycoreobjectrosdok_disshab_0000000787rosdok_disshab_0000000787rosdokdisshabrosdok_derivate_00000048162023-08-08T10:03:12.331Z2012-02-01T15:05:59.953Zadministratorpublished1rosdok_derivate_0000004816truetruederivate_types:fulltextVolltextfulltextwf_edit_epub wf_register_epubstate:publishedstate:publishedveröffentlichtpublishedrosdok/id00000972684559005MODS updated during RosDok migration in June 2021DissertationHochschulschrift1019146591OrianneMazemondet1981-VerfasserInautSpatio-temporal Dynamics of the Wnt/beta-catenin Signaling PathwayA Computational Systems Biology ApproachenProf. Dr. rer. nat. habil.Adelinde M.UhrmacherAkademischeR BetreuerIndgsProf. Dr. med.ArndtRolfsAkademischeR BetreuerIndgsProf. Dr.James R.FaederAkademischeR BetreuerIndgs10085032-7Universität RostockFakultät für Informatik und ElektrotechnikGrad-verleihende Institutiondgg10.18453/rosdok_id00000972http://purl.uni-rostock.de/rosdok/id00000972urn:nbn:de:gbv:28-diss2012-0005-4570 Biowissenschaften, BiologieFakultät für Informatik und Elektrotechnikfrei zugänglich (Open Access)Lizenz Metadaten: CC0Nutzungsrechte erteiltalle Rechte vorbehaltenUniversität RostockRostock2011monographic20112011Universitätsbibliothek RostockRostock20122012The Wnt/β-catenin signaling pathway is involved in human neural progenitor cell differentiation. This dissertation employs the cyclic workflow of computational systems biology to investigate the pathway spatio-temporal dynamics during differentiation. Quantitative in vitro analyses show biphasic kinetics of the pathway proteins. A computational model is developed to investigate in silico these kinetics in correlation with cell cycle and self-induced signaling. We show the importance of stochastic approach and suggest further experiments, hence closing the computational systems biology loop.computational systems biologyReNcell VM cellsstochastic modelingSystembiologieWnt/beta-catenin SignalwegReNcell VM ZellenStochastic ModellierungUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00000972doctype:epubdoctype:epubDokumenttypDocument typedoctype:epub.dissertationdoctype:epub.dissertationDissertationdoctoral thesisdiniPublType:doctoralThesis diniPublType2022:PhDThesis XMetaDissPlusThesisLevel:thesis.doctoralinfo:eu-repo/semantics/doctoralThesisdocumentnatureOfContent:ppn_105825778natureOfContent:ppn_105825778HochschulschriftdiniPublType2022:DoctoralThesisdiniPublType2022:DoctoralThesisDissertation oder HabilitationDoctoral thesisDRIVERdiniPublType2022:PhDThesisdiniPublType2022:PhDThesisDissertationPhD thesisKDSF (Pu34)XMetaDissPlusThesisLevel:thesis.doctoralXMetaDissPlusThesisLevel:thesis.doctoralDoktorarbeitdoctoral thesisrfc5646:enrfc5646:enEnglischEnglishengengSDNB:570SDNB:570570 Biowissenschaften, Biologie570 Life scienceinstitution:unirostockinstitution:unirostockUniversität RostockUniversity of RostockUniversität RostockUniversität RostockUni.Rostockhttp://d-nb.info/gnd/38329-6institution:unirostock.iefinstitution:unirostock.iefFakultät für Informatik und ElektrotechnikFaculty of Computer Science and Electrical EngineeringUniversität Rostock. Fakultät für Informatik und ElektrotechnikFakultät für Informatik<br />und ElektrotechnikUni.Rostock.Fakultaet.IEFhttp://d-nb.info/gnd/10085032-7accesscondition:openaccessaccesscondition:openaccessfrei zugänglich (Open Access)open accesshttp://purl.org/coar/access_right/c_abf2OAfreeinfo:eu-repo/semantics/openAccess[DE-28]Open Access$gControlled Vocabulary for Access Rights$uhttp://purl.org/coar/access_right/c_abf2licenseinfo:metadatalicenseinfo:metadataLizenzen für Metadatenlicenseinfo:metadata.cc0licenseinfo:metadata.cc0Lizenz Metadaten: CC0license metadata: CC0/creativecommons/p/zero/1.0/88x31.pnghttps://creativecommons.org/publicdomain/zero/1.0/licenseinfo:depositlicenseinfo:depositVeröffentlichungsgenehmigungpermission to storelicenseinfo:deposit.rightsgrantedlicenseinfo:deposit.rightsgrantedNutzungsrechte erteiltrights grantedlicenseinfo:worklicenseinfo:workWerkworklicenseinfo:work.rightsreservedlicenseinfo:work.rightsreservedalle Rechte vorbehaltenall rights reserved/creativecommons/r/reserved/0.9/88x31.png[DE-28]Urheberrechtsschutz 1.0$gRights Statements$uhttp://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/Spatio-temporal Dynamics of the Wnt/beta-catenin Signaling PathwayA Computational Systems Biology ApproachSpatio-temporal Dynamics of the Wnt/beta-catenin Signaling PathwayA Computational Systems Biology Approachgnd:1019146591gnd:10085032-7gnd:1019146591gnd:10085032-7rosdok_disshab_0000000787-d580567e39gnd:1019146591Orianne MazemondetOrianne Mazemondetrosdok_disshab_0000000787-d580567e61Prof. Dr. rer. nat. habil. 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FaederUniversität Rostock Fakultät für Informatik und ElektrotechnikOrianne MazemondetRostockUniversität Rostockepub.dissertation10.18453/rosdok_id00000972http://purl.uni-rostock.de/rosdok/id00000972urn:nbn:de:gbv:28-diss2012-0005-4computational systems biologyReNcell VM cellsstochastic modelingSystembiologieWnt/beta-catenin SignalwegReNcell VM ZellenStochastic ModellierungThe Wnt/β-catenin signaling pathway is involved in human neural progenitor cell differentiation. This dissertation employs the cyclic workflow of computational systems biology to investigate the pathway spatio-temporal dynamics during differentiation. Quantitative in vitro analyses show biphasic kinetics of the pathway proteins. A computational model is developed to investigate in silico these kinetics in correlation with cell cycle and self-induced signaling. 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This dissertation employs the cyclic workflow of computational systems biology to investigate the pathway spatio-temporal dynamics during differentiation. Quantitative in vitro analyses show biphasic kinetics of the pathway proteins. A computational model is developed to investigate in silico these kinetics in correlation with cell cycle and self-induced signaling. We show the importance of stochastic approach and suggest further experiments, hence closing the computational systems biology loop.computational systems biologyReNcell VM cellsstochastic modelingSystembiologieWnt/beta-catenin SignalwegReNcell VM ZellenStochastic ModellierungUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00000972 2012-02-01T15:05:59.953Z 2023-08-08T10:03:12.331Z 2023-08-18T10:03:12.336Z {"identifier":"rosdok/id00000972","type":"local_id","additional":"","service":"MCRLocalID","created":"2018-06-30T12:55:48.739Z"} {"identifier":"http://purl.uni-rostock.de/rosdok/id00000972","type":"purl","additional":"","service":"RosDokPURL","created":"2018-06-30T12:55:48.909Z","registered":"2018-06-30T12:55:48.909Z"} {"identifier":"10.18453/rosdok_id00000972","type":"doi","additional":"","service":"RosDokDOI","created":"2018-06-30T12:55:50.169Z","registered":"2018-06-30T12:55:50.169Z"} {"identifier":"urn:nbn:de:gbv:28-diss2012-0005-4","type":"dnbUrn","additional":"","service":"RosDokURN","created":"2018-06-30T12:55:48.744Z","registered":"2012-02-02T03:01:54.400Z"} administratorfulltextfile/rosdok_disshab_0000000787/rosdok_derivate_0000004816/Dissertation_Mazemondet_2012.pdfSpatio-temporal Dynamics of the Wnt/beta-catenin Signaling PathwayA Computational Systems Biology ApproachSpatio-temporal Dynamics of the Wnt/beta-catenin Signaling PathwayA Computational Systems Biology Approachgnd:1019146591gnd:10085032-7gnd:1019146591gnd:10085032-7rosdok_disshab_0000000787-d580567e39gnd:1019146591Orianne MazemondetOrianne Mazemondetrosdok_disshab_0000000787-d580567e61Prof. Dr. rer. nat. habil. Adelinde M. UhrmacherProf. Dr. rer. nat. habil. Adelinde M. Uhrmacherrosdok_disshab_0000000787-d580567e73Prof. Dr. med. Arndt RolfsProf. Dr. med. Arndt Rolfsrosdok_disshab_0000000787-d580567e85Prof. Dr. James R. FaederProf. Dr. James R. Faederrosdok_disshab_0000000787-d580567e98gnd:10085032-7Universität Rostock Fakultät für Informatik und ElektrotechnikUniversität Rostock Fakultät für Informatik und ElektrotechnikOrianne MazemondetProf. Dr. rer. nat. habil. Adelinde M. UhrmacherProf. Dr. med. Arndt RolfsProf. Dr. James R. FaederUniversität Rostock Fakultät für Informatik und ElektrotechnikOrianne MazemondetProf. Dr. rer. nat. habil. Adelinde M. UhrmacherProf. Dr. med. Arndt RolfsProf. Dr. James R. FaederUniversität Rostock Fakultät für Informatik und ElektrotechnikOrianne MazemondetRostockUniversität Rostockepub.dissertation10.18453/rosdok_id00000972http://purl.uni-rostock.de/rosdok/id00000972urn:nbn:de:gbv:28-diss2012-0005-4computational systems biologyReNcell VM cellsstochastic modelingSystembiologieWnt/beta-catenin SignalwegReNcell VM ZellenStochastic ModellierungThe Wnt/β-catenin signaling pathway is involved in human neural progenitor cell differentiation. This dissertation employs the cyclic workflow of computational systems biology to investigate the pathway spatio-temporal dynamics during differentiation. Quantitative in vitro analyses show biphasic kinetics of the pathway proteins. A computational model is developed to investigate in silico these kinetics in correlation with cell cycle and self-induced signaling. We show the importance of stochastic approach and suggest further experiments, hence closing the computational systems biology loop.20112011[xslt]Saxonrosdok/id00000972https://purl.uni-rostock.de/rosdok/id0000097268455900510.18453/rosdok_id00000972urn:nbn:de:gbv:28-diss2012-0005-4Orianne MazemondetMazemondet OrianneSpatio-temporal Dynamics of the Wnt/beta-catenin Signaling Pathway : A Computational Systems Biology ApproachDissertationdoctoral thesisUniversität Rostock, 2011The Wnt/β-catenin signaling pathway is involved in human neural progenitor cell differentiation. This dissertation employs the cyclic workflow of computational systems biology to investigate the pathway spatio-temporal dynamics during differentiation. Quantitative in vitro analyses show biphasic…Orianne MazemondetSpatio-temporal Dynamics of the Wnt/beta-catenin Signaling PathwayA Computational Systems Biology ApproachUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id000009721019146591OrianneMazemondet1981-VerfasserInautProf. Dr. rer. nat. habil.Adelinde M.UhrmacherAkademischeR BetreuerIndgsProf. Dr. med.ArndtRolfsAkademischeR BetreuerIndgsProf. Dr.James R.FaederAkademischeR BetreuerIndgs10085032-7Universität RostockFakultät für Informatik und ElektrotechnikGrad-verleihende Institutiondgg[doi]10.18453/rosdok_id00000972[purl]http://purl.uni-rostock.de/rosdok/id00000972[urn]urn:nbn:de:gbv:28-diss2012-0005-4open_access20112011epoch:21th_centuryrfc5646:endoctype:epub.dissertationaccesscondition:openaccessSDNB:570institution:unirostock.iefstate:published